PKCTheta-IN-2

Cat. No.: HY-164756 Purity: 99.49%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC₅₀ of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases). PKCTheta-IN-2 inhibits the IL-2 production in a mouse (IC₅₀ of 682 nM).

For research use only. We do not sell to patients.

PKCTheta-IN-2 Chemical Structure

CAS No. : 1810742-60-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & TargetPKC

PKCθ

0.25 nM (IC₅₀)

Molecular Weight

413.47

Formula

C₂₄H₂₃N₅O₂

CAS No.

1810742-60-9

Appearance

Solid

Color

White to off-white

SMILES

C[C@H](C1=CC=CC=C1)N2C3=CC(N4C5=CC=CN=C5NC4=O)=CC=C3C(NC2(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (302.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4186 mL	12.0928 mL	24.1856 mL
5 mM	0.4837 mL	2.4186 mL	4.8371 mL
10 mM	0.2419 mL	1.2093 mL	2.4186 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.49%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (257 KB) HNMR (260 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Taisuke Katoh, et al. Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors. Bioorg Med Chem. 2016 Jun 1;24(11):2466-2475. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4186 mL	12.0928 mL	24.1856 mL	60.4639 mL
	5 mM	0.4837 mL	2.4186 mL	4.8371 mL	12.0928 mL
	10 mM	0.2419 mL	1.2093 mL	2.4186 mL	6.0464 mL
	15 mM	0.1612 mL	0.8062 mL	1.6124 mL	4.0309 mL
	20 mM	0.1209 mL	0.6046 mL	1.2093 mL	3.0232 mL
	25 mM	0.0967 mL	0.4837 mL	0.9674 mL	2.4186 mL
	30 mM	0.0806 mL	0.4031 mL	0.8062 mL	2.0155 mL
	40 mM	0.0605 mL	0.3023 mL	0.6046 mL	1.5116 mL
	50 mM	0.0484 mL	0.2419 mL	0.4837 mL	1.2093 mL
	60 mM	0.0403 mL	0.2015 mL	0.4031 mL	1.0077 mL
	80 mM	0.0302 mL	0.1512 mL	0.3023 mL	0.7558 mL
	100 mM	0.0242 mL	0.1209 mL	0.2419 mL	0.6046 mL

PKCTheta-IN-2 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKCTheta-IN-21810742-60-9PKCProtein kinase CPKCθ inhibitorIL-2 productionInhibitorinhibitorinhibit

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