2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. PNU-159682 carboxylic acid

PNU-159682 carboxylic acid (compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response.

For research use only. We do not sell to patients.

PNU-159682 carboxylic acid Chemical Structure

PNU-159682 carboxylic acid Chemical Structure

CAS No. : 1204819-92-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1520 In-stock
Solution
10 mM * 1 mL in DMSO USD 1520 In-stock
Solid
1 mg USD 450 In-stock
5 mg USD 1100 In-stock
10 mg USD 1820 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

PNU-159682 carboxylic acid Related Antibodies

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Description

PNU-159682 carboxylic acid (compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response[1].

IC50 & Target[1]

Daunorubicins/Doxorubicins

 

Molecular Weight

627.59

Formula

C31H33NO13
CAS No.
Appearance

Solid

Color

Brown to red

SMILES

C[C@H]1[C@]2([H])[C@](N3[C@]([C@H](OCC3)OC)([H])O2)([H])C[C@](O1)([H])O[C@@H]4C5=C(C[C@](C(O)=O)(O)C4)C(O)=C6C(C(C7=C(OC)C=CC=C7C6=O)=O)=C5O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (79.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5934 mL 7.9670 mL 15.9340 mL
5 mM 0.3187 mL 1.5934 mL 3.1868 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5934 mL 7.9670 mL 15.9340 mL 39.8349 mL
5 mM 0.3187 mL 1.5934 mL 3.1868 mL 7.9670 mL
10 mM 0.1593 mL 0.7967 mL 1.5934 mL 3.9835 mL
15 mM 0.1062 mL 0.5311 mL 1.0623 mL 2.6557 mL
20 mM 0.0797 mL 0.3983 mL 0.7967 mL 1.9917 mL
25 mM 0.0637 mL 0.3187 mL 0.6374 mL 1.5934 mL
30 mM 0.0531 mL 0.2656 mL 0.5311 mL 1.3278 mL
40 mM 0.0398 mL 0.1992 mL 0.3983 mL 0.9959 mL
50 mM 0.0319 mL 0.1593 mL 0.3187 mL 0.7967 mL
60 mM 0.0266 mL 0.1328 mL 0.2656 mL 0.6639 mL
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PNU-159682 carboxylic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNU-159682 carboxylic acid1204819-92-0ADC CytotoxinADC PayloadC-typelectindomainCTLCTLDproteinfoldcelladhesionsignallingglycoproteinturnoverInhibitorinhibitorinhibit

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