Poly-L-lysine (hydrobromide) (MW 150000-300000)

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Poly-L-lysine hydrobromide (MW 150000-300000) is a lysine polymer. Poly-L-lysine hydrobromide is a nonspecific attachment factor for cells, promoting cell adhesion to solid substrates. Poly-L-lysine hydrobromide can be used as a coating substrate for culture dishes, slides, etc. Poly-L-lysine hydrobromide (MW 150000-300000) exhibits anticancer activity against melanoma and lymphoma. Poly-L-lysine hydrobromide (MW 150000-300000) can be used for combined hyperthermia, magnetic resonance imaging, and cancer cell detection.

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Poly-L-lysine (hydrobromide) (MW 150000-300000) Chemical Structure

CAS No. : 25988-63-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Poly-L-lysine (hydrobromide) (MW 150000-300000):

Poly-L-lysine (hydrobromide) (MW 30000-70000) Get quote
Poly-L-lysine hydrochloride Get quote
Poly-L-lysine hydrobromide (MW 70000-150000) Get quote
Poly-L-lysine hydrobromide (MW ＞300000) Get quote

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Purity & Documentation
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Description	Poly-L-lysine hydrobromide (MW 150000-300000) is a lysine polymer. Poly-L-lysine hydrobromide is a nonspecific attachment factor for cells, promoting cell adhesion to solid substrates. Poly-L-lysine hydrobromide can be used as a coating substrate for culture dishes, slides, etc. Poly-L-lysine hydrobromide (MW 150000-300000) exhibits anticancer activity against melanoma and lymphoma. Poly-L-lysine hydrobromide (MW 150000-300000) can be used for combined hyperthermia, magnetic resonance imaging, and cancer cell detection^[1]^[2]^[3]^[4]^[5].
In Vitro	Poly-L-lysine hydrobromide (MW 150000-300000) (0-500 µg/mL, 67 h) shows cytotoxicity in B16F10 and L1210 cells, with IC₅₀s of 25 and 275 µg/mL^[2]. Poly-L-lysine hydrobromide (MW 150000-300000)-designed magnetic nanoparticles can be used for combined hyperthermia, magnetic resonance imaging, and cancer cell detection^[3]. Poly-L-lysine hydrobromide (MW 150000-300000) inhibits MHCK A phosphorylation of the synthetic peptide MH-3 with an IC₅₀ value of close to 0.5 µg/mL^[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Poly-L-lysine (hydrobromide) (MW 150000-300000) Related Antibodies
In Vivo	Poly-L-lysine hydrobromide (MW 150000-300000) synthesizes nanoclusters (i.v.) for imaging orthodox endometriosis lesions with negative contrast in mice^[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	150000-300000
Formula	C₈H₁₉BrN₂O
CAS No.	25988-63-0
Appearance	Solid
Color	White to yellow
SMILES	CN[C@@H](CCCC[NH3+])C(C)=O.[n].[Br-].[n]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility	In Vitro: H₂O : 125 mg/mL (Need ultrasonic) Molarity Calculator Dilution Calculator Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Mass = Concentration × Volume × Molecular Weight * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) This equation is commonly abbreviated as: C₁V₁ = C₂V₂ Concentration _(start) C1 × Volume _(start) V1 = Concentration _(final) C2 × Volume _(final) V2 In Vivo: Select the appropriate dissolution method based on your experimental animal and administration route. For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents: To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day. The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution. Protocol 1 Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline Solubility: ≥ 2.5 mg/mL; Clear solution This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL. Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution. Protocol 2 Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline) Solubility: ≥ 2.5 mg/mL; Clear solution This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear. In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kg Animal weight (per animal) g Dosing volume (per animal) μL Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details. The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE). Tel: 609-228-6898 E-mail: sales@medchemexpress.com Technical Support: tech@medchemexpress.com
Purity & Documentation	Select Batch: Data Sheet (272 KB) SDS (393 KB) COA (246 KB) Handling Instructions (2659 KB)
References	[1]. D Mazia, et al. Adhesion of cells to surfaces coated with polylysine. Applications to electron microscopy. J Cell Biol. 1975 Jul;66(1):198-200. [Content Brief] [2]. Ferruti P, et al. A novel modification of poly (l‐lysine) leading to a soluble cationic polymer with reduced toxicity and with potential as a transfection agent. Macromolecular Chemistry and Physics, 1998, 199(11): 2565-2575. [3]. Kubovcikova M, et al. Poly-L-lysine designed magnetic nanoparticles for combined hyperthermia, magnetic resonance imaging and cancer cell detection. Journal of Magnetism and Magnetic Materials, 2019, 475: 316-326. [4]. Medley QG, et al. Dictyostelium myosin II heavy-chain kinase A is activated by heparin, DNA and acidic phospholipids and inhibited by polylysine, polyarginine and histones. Biochim Biophys Acta. 1992 Dec 15;1175(1):7-12. [Content Brief] [5]. Lv Q, et al. An Indocyanine Green-Based Nanocluster for Imaging Orthodox Endometriosis Lesions with Negative Contrast. ACS Appl Mater Interfaces. 2024 May 22;16(20):25909-25922. [Content Brief]