Polyketomycin

Cat. No.: HY-106338: FAQs
Data Sheet Handling Instructions

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Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities.

For research use only. We do not sell to patients.

Polyketomycin Chemical Structure

CAS No. : 200625-47-4

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1 mg	Get quote	Estimated Time of Arrival: December 31
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]^[2]

Plasmodium

Traditional Cytotoxic Agents

In Vitro

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC₅₀ values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The acute toxicity (LD₅₀, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

864.84

Formula

C₄₄H₄₈O₁₈

CAS No.

200625-47-4

SMILES

O[C@]1([C@@H]2O[C@]3([H])O[C@@H]([C@@H](O[C@@]4([H])C[C@@](O)([C@H](OC(C5=C(C(C)=CC=C5C)O)=O)[C@H](C)O4)C)CC3)C)[C@](C(C6=C(C(C)=C7C(C(C=C(OC)C7=O)=O)=C6O)C1)=O)(C(/C(C2=O)=C(O)\C)=O)O

Structure Classification

Initial Source

Microorganisms

Streptomyces sp. MK277-AF1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Momose I, et al. Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1998 Jan;51(1):21-5. [Content Brief]

[2]. Daum M, et al. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem. 2009 Apr 17;10(6):1073-83. [Content Brief]

[3]. Otoguro K, In vitro antimalarial activities of the microbial metabolites. J Antibiot (Tokyo). 2003 Mar;56(3):322-4. [Content Brief]

Polyketomycin Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polyketomycin200625-47-4BacterialADC CytotoxinParasiteADC PayloadADCCytotoxinMRSAantibioticanticancertetracyclicquinoneglycosideantimalarialInhibitorinhibitorinhibit

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