Pomalidomide-d₃ (Synonyms: CC-4047-d₃)

Name: Pomalidomide-d 3
Brand: MedChemExpress
SKU: HY-10984S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-10984S1 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Pomalidomide-d₃ is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors[1][2].

For research use only. We do not sell to patients.

Pomalidomide-d<sub>3</sub> Chemical Structure

Pomalidomide-d₃ Chemical Structure

CAS No. : 2093128-28-8

Size	Price	Stock	Quantity
1 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Pomalidomide In-stock

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

276.26

Formula

C₁₃H₈D₃N₃O₄

CAS No.

2093128-28-8

Unlabeled CAS

19171-19-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2C(NC(CC2)=O)=O)C(C3=C(N)C([2H])=C([2H])C([2H])=C31)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (180.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6198 mL	18.0989 mL	36.1978 mL
5 mM	0.7240 mL	3.6198 mL	7.2396 mL
10 mM	0.3620 mL	1.8099 mL	3.6198 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Zhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54(4):683-7. [Content Brief]

[3]. Hernandez-Ilizaliturri FJ1, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res. 2005 Aug 15;11(16):5984-92. [Content Brief]

[4]. Schafer PH, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J Pharmacol Exp Ther. 2003 Jun;305(3):1222-32. [Content Brief]

[5]. Li Z, et al. Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models. PLoS One. 2013 Aug 5;8(8):e71754. [Content Brief]

[6]. Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22(6):755-63. [Content Brief]

[7]. Liu D, et al. Tumour necrosis factor-α inhibits hepatic lipid deposition through GSK-3β/β-catenin signaling in juvenile turbot (Scophthalmus maximus L.). Gen Comp Endocrinol. 2016 Mar 1;228:1-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	3.6198 mL	18.0989 mL	36.1978 mL	90.4945 mL
	5 mM	0.7240 mL	3.6198 mL	7.2396 mL	18.0989 mL
	10 mM	0.3620 mL	1.8099 mL	3.6198 mL	9.0494 mL
	15 mM	0.2413 mL	1.2066 mL	2.4132 mL	6.0330 mL
	20 mM	0.1810 mL	0.9049 mL	1.8099 mL	4.5247 mL
	25 mM	0.1448 mL	0.7240 mL	1.4479 mL	3.6198 mL
	30 mM	0.1207 mL	0.6033 mL	1.2066 mL	3.0165 mL
	40 mM	0.0905 mL	0.4525 mL	0.9049 mL	2.2624 mL
	50 mM	0.0724 mL	0.3620 mL	0.7240 mL	1.8099 mL
	60 mM	0.0603 mL	0.3016 mL	0.6033 mL	1.5082 mL
	80 mM	0.0452 mL	0.2262 mL	0.4525 mL	1.1312 mL
	100 mM	0.0362 mL	0.1810 mL	0.3620 mL	0.9049 mL

Pomalidomide-d₃ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-d₃2093128-28-8CC-4047-d₃Ligands for E3 LigaseMolecular GluesApoptosisE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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Pomalidomide-d3 (Synonyms: CC-4047-d3)

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Pomalidomide-d₃ (Synonyms: CC-4047-d₃)

Other Forms of Pomalidomide-d₃:

Pomalidomide-d₃ Related Antibodies

Pomalidomide-d₃ Related Antibodies

Pomalidomide-d₃ Related Classifications