2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Cell Cycle/DNA Damage JAK/STAT Signaling
  3. c-Met/HGFR PI3K DNA-PK mTOR Bcr-Abl Src VEGFR EGFR PDGFR
  4. PP487

PP487 is a dual inhibitor of tyrosine kinase/PI(3)Ks with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used for cancer research.

For research use only. We do not sell to patients.

PP487 Chemical Structure

PP487 Chemical Structure

CAS No. : 1092787-12-6

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PP487 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

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Lck Fyn Blk

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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PDGFR PDGFRβ PDGFRα

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Description

PP487 is a dual inhibitor of tyrosine kinase/PI(3)Ks with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used for cancer research[1].

IC50 & Target

p110α

0.046 μM (IC50)

p110β

0.24 μM (IC50)

p110δ

0.027 μM (IC50)

p110γ

0.1 μM (IC50)

Abl

0.021 μM (IC50)

VEGFR2

0.055 μM (IC50)

Molecular Weight

348.20

Formula

C14H14BrN5O
CAS No.
SMILES

BrC1=C(O)C=C(C2=NN(C(C)C)C3=C2C(N)=NC=N3)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PP487 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PP4871092787-12-6PP 487PP-487c-Met/HGFRPI3KDNA-PKmTORBcr-AblSrcVEGFREGFRPDGFRPhosphoinositide 3-kinaseDNA-dependent protein kinaseMammalian target of RapamycinVascular endothelial growth factor receptorEpidermal growth factor receptorErbB-1HER1Platelet-derived growth factor receptorCancerInhibitorinhibitorinhibit

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