PRMT4-IN-1

Cat. No.: HY-146810: FAQs
Data Sheet Handling Instructions

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PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC₅₀=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability.

For research use only. We do not sell to patients.

PRMT4-IN-1 Chemical Structure

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•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description

PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC₅₀=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability^[1].

IC₅₀ & Target^[1]

PRMT1

0.835 μM (IC₅₀)

PRMT3

4.05 μM (IC₅₀)

PRMT4

3.2 nM (IC₅₀)

PRMT5

1.46 μM (IC₅₀)

PRMT6

1.75 μM (IC₅₀)

PRMT7

1.68 μM (IC₅₀)

PRMT8

1.95 μM (IC₅₀)

In Vitro

PRMT4-IN-1 (compound 12h) (10 μM, 50 μM, 100 μM; 24 h, 72 h) shows no effect on reduction the number of metabolically active cells^[1]. PRMT4-IN-1 (50 μM; 2-8 d) decreases relative cell viability time-dependently in MCF7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

648.67

Formula

C₃₀H₃₆N₁₀O₇

SMILES

O=C(OC)C1=CC(O)=C2C=C(NC(NCCCCNC(NC/C=C/[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=N)=O)C=CC2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Iannelli G, et al. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem. 2022 Sep 8;65(17):11574-11606. [Content Brief]

PRMT4-IN-1 Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT4-IN-1Histone MethyltransferaseMCF-7 cellsbreast cancerInhibitorinhibitorinhibit

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