Procaterol hydrochloride hemihydrate  (Synonyms: OPC 2009 hydrochloride hemihydrate)

Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist. Procaterol hydrochloride hemihydrate can be used for the research of asthma^[1][2][3].

Procaterol hydrochloride hemihydrate (0.1 μM, 24-72 h) decreases rhinovirus infection in human tracheal epithelial cells^[4].
Procaterol hydrochloride hemihydrate (0-1 μg/mL, 24/48 h) inhibits IL-1β- and TNF-α-mediated eosinophil chemotactic activity in BEAS-2B cell^[5].
procaterol hydrochloride hemihydrate (25-200 nM, 20 h) protects 16HBE cells from H₂O₂-induced oxidative stress^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Procaterol hydrochloride hemihydrate (1, 3 or 10 μg/mL, inhaled administration) inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation^[2].
Procaterol hydrochloride hemihydrate (0.1 mg/kg, i.p.) completely abolishes both the Mch-induced cough in conscious guinea pigs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

335.82

C₁₆H₂₃ClN₂O₃.1/2H₂O

81262-93-3

Solid

White to off-white

O[C@H]([C@H](NC(C)C)CC)C1=C(C=CC(N2)=O)C2=C(O)C=C1.Cl.[0.5 H2O]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Tukiainen H, et al. Comparison between oral procaterol and salbutamol in patients with bronchial asthma. Curr Med Res Opin. 1988;11(4):236-41.  [Content Brief]

  [2]. Mirza ZN, et al. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation. Clin Exp Allergy. 1998 May;28(5):644-52.  [Content Brief]

  [3]. Ohkura N, et al. Bronchoconstriction-triggered cough in conscious guinea pigs. Exp Lung Res. 2009 May;35(4):296-306.  [Content Brief]

  [4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44.  [Content Brief]

  [5]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75.  [Content Brief]

  [6]. Deng Z, et al. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50.  [Content Brief]