2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Procaterol hydrochloride

Procaterol hydrochloride is a selective intermediate-acting β2 adrenoreceptor agonist with an EC50 of 12.9 μM. Procaterol hydrochloride can inhibit inflammation both in vivo and in vitro.

For research use only. We do not sell to patients.

Procaterol hydrochloride Chemical Structure

Procaterol hydrochloride Chemical Structure

CAS No. : 62929-91-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Procaterol hydrochloride:

Procaterol hydrochloride Related Antibodies

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1 Publications Citing Use of MCE Procaterol hydrochloride

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α adrenergic receptor β adrenergic receptor

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Description

Procaterol hydrochloride is a selective intermediate-acting β2 adrenoreceptor agonist with an EC50 of 12.9 μM[1]. Procaterol hydrochloride can inhibit inflammation both in vivo and in vitro[2].

In Vitro

Procaterol treat inflammation through inhibiting oxidative stress in vitro[2].
Procaterol (25-200 nM) increases the viability of 16HBE cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Procaterol hydrochloride Related Antibodies

Cell Viability Assay[2]

Cell Line: The immortal human bronchial epithelial cell line (16HBE)
Concentration: 25-200 nM
Incubation Time: Pretreated for 20 hours
Result: Pretreatment elevated the cell viability rate in a dose-dependent manner. Pretreatment with Procaterol plus Dexamethasone could also significantly increase the cell viability rate, but the combined effect was not better than sole pretreatment with an identical dose of Procaterol.
In Vivo

Procaterol significantly increases conditioned stimulus (CS)-evoked freezing levels[3]. Propranolol-mediated blockade of β-adrenergic receptors (β-ARs) significantly reduces behavioral expression of Pavlovian threat conditioning (PTC), whereas systemic activation of β2-ARs using Procaterol enhances it[3].
Procaterol hydrochloride is freshly dissolved in 0.9% sterile saline immediately prior to injections[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats, weighing 250-275 g (~60-70 days old)[3]
Dosage: 300 µg/kg
Administration: Intraperitoneal (IP) injection
Result: Systemic injection of the specific β2-AR agonist procaterol (300 µg/kg) enhanced CS-elicited freezing during the expression test, with no effect during a drug free test.
Molecular Weight

326.82

Formula

C16H23ClN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C([C@H](O)[C@H](NC(C)C)CC)=CC=C2O)C=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (91.79 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0598 mL 15.2989 mL 30.5979 mL
5 mM 0.6120 mL 3.0598 mL 6.1196 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0598 mL 15.2989 mL 30.5979 mL 76.4947 mL
5 mM 0.6120 mL 3.0598 mL 6.1196 mL 15.2989 mL
10 mM 0.3060 mL 1.5299 mL 3.0598 mL 7.6495 mL
15 mM 0.2040 mL 1.0199 mL 2.0399 mL 5.0996 mL
20 mM 0.1530 mL 0.7649 mL 1.5299 mL 3.8247 mL
25 mM 0.1224 mL 0.6120 mL 1.2239 mL 3.0598 mL
30 mM 0.1020 mL 0.5100 mL 1.0199 mL 2.5498 mL
40 mM 0.0765 mL 0.3825 mL 0.7649 mL 1.9124 mL
50 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5299 mL
60 mM 0.0510 mL 0.2550 mL 0.5100 mL 1.2749 mL
80 mM 0.0382 mL 0.1912 mL 0.3825 mL 0.9562 mL
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Procaterol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Procaterol62929-91-3Adrenergic ReceptorBeta Receptorintermediate-actingβ2adrenoreceptorinflammationInhibitorinhibitorinhibit

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