Progranulin modulator-3

Name: Progranulin modulator-3
Brand: MedChemExpress
SKU: HY-161903
Rating: 4.5 (1 reviews)

Cat. No.: HY-161903 Purity: 99.95%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Progranulin modulator-3 (compd C40) is a brain-penetrant and orally active progranulin (PGRN) inducer. Progranulin modulator-3 can be used for neurological research.

For research use only. We do not sell to patients.

Progranulin modulator-3 Chemical Structure

CAS No. : 371116-39-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 121	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 121	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 375	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Progranulin modulator-3 (compd C40) is a brain-penetrant and orally active progranulin (PGRN) inducer. Progranulin modulator-3 can be used for neurological research^[1].

In Vitro

Progranulin modulator-3 (1-30 μM, 48 h) induces PGRN protein production does-dependently in N2A cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Progranulin modulator-3 (10 mg/kg, i.p., 24h) shows a half life of 41 min and C_maxs of 1498 ng/mL and 6246 ng/g in mice plasma and brain, respectively, and increases PGRN protein levels in Grn+/− mouse brains^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

304.30

Formula

C₁₈H₁₂N₂O₃

CAS No.

371116-39-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=CO1)NC2=CC=C3C(N=C(C4=CC=CC=C4)O3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (328.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2862 mL	16.4312 mL	32.8623 mL
5 mM	0.6572 mL	3.2862 mL	6.5725 mL
10 mM	0.3286 mL	1.6431 mL	3.2862 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (247 KB) HNMR (209 KB) RP-HPLC (258 KB) LCMS (156 KB)

Handling Instructions (2659 KB)

References

[1]. Tesla R, et al. Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency. Nat Commun. 2024 Jul 20;15(1):6125. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2862 mL	16.4312 mL	32.8623 mL	82.1558 mL
	5 mM	0.6572 mL	3.2862 mL	6.5725 mL	16.4312 mL
	10 mM	0.3286 mL	1.6431 mL	3.2862 mL	8.2156 mL
	15 mM	0.2191 mL	1.0954 mL	2.1908 mL	5.4771 mL
	20 mM	0.1643 mL	0.8216 mL	1.6431 mL	4.1078 mL
	25 mM	0.1314 mL	0.6572 mL	1.3145 mL	3.2862 mL
	30 mM	0.1095 mL	0.5477 mL	1.0954 mL	2.7385 mL
	40 mM	0.0822 mL	0.4108 mL	0.8216 mL	2.0539 mL
	50 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6431 mL
	60 mM	0.0548 mL	0.2739 mL	0.5477 mL	1.3693 mL
	80 mM	0.0411 mL	0.2054 mL	0.4108 mL	1.0269 mL
	100 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.8216 mL