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Progranulin modulator-3 (compd C40) is a brain-penetrant and orally active progranulin (PGRN) inducer. Progranulin modulator-3 can be used for neurological research.

For research use only. We do not sell to patients.

Progranulin modulator-3 Chemical Structure

Progranulin modulator-3 Chemical Structure

CAS No. : 371116-39-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 121 In-stock
Solution
10 mM * 1 mL in DMSO USD 121 In-stock
Solid
5 mg USD 110 In-stock
10 mg USD 180 In-stock
25 mg USD 375 In-stock
50 mg USD 600 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Progranulin modulator-3 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Progranulin modulator-3 (compd C40) is a brain-penetrant and orally active progranulin (PGRN) inducer. Progranulin modulator-3 can be used for neurological research[1].

In Vitro

Progranulin modulator-3 (1-30 μM, 48 h) induces PGRN protein production does-dependently in N2A cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Progranulin modulator-3 Related Antibodies
In Vivo

Progranulin modulator-3 (10 mg/kg, i.p., 24h) shows a half life of 41 min and Cmaxs of 1498 ng/mL and 6246 ng/g in mice plasma and brain, respectively, and increases PGRN protein levels in Grn+/− mouse brains[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

304.30

Formula

C18H12N2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=CO1)NC2=CC=C3C(N=C(C4=CC=CC=C4)O3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (328.62 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2862 mL 16.4312 mL 32.8623 mL
5 mM 0.6572 mL 3.2862 mL 6.5725 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2862 mL 16.4312 mL 32.8623 mL 82.1558 mL
5 mM 0.6572 mL 3.2862 mL 6.5725 mL 16.4312 mL
10 mM 0.3286 mL 1.6431 mL 3.2862 mL 8.2156 mL
15 mM 0.2191 mL 1.0954 mL 2.1908 mL 5.4771 mL
20 mM 0.1643 mL 0.8216 mL 1.6431 mL 4.1078 mL
25 mM 0.1314 mL 0.6572 mL 1.3145 mL 3.2862 mL
30 mM 0.1095 mL 0.5477 mL 1.0954 mL 2.7385 mL
40 mM 0.0822 mL 0.4108 mL 0.8216 mL 2.0539 mL
50 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.6431 mL
60 mM 0.0548 mL 0.2739 mL 0.5477 mL 1.3693 mL
80 mM 0.0411 mL 0.2054 mL 0.4108 mL 1.0269 mL
100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8216 mL
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Progranulin modulator-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Progranulin modulator-3371116-39-1Progranulin modulator3Progranulin modulator 3Othersbrain-penetrantorally activePGRNneurologicalN2AGrn+/? mouseInhibitorinhibitorinhibit

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