Promethazine-d₄ hydrochloride

Name: Promethazine-d 4 hydrochloride
Brand: MedChemExpress
SKU: HY-B0781S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0781S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Promethazine-d₄ (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.

For research use only. We do not sell to patients.

Promethazine-d<sub>4</sub> hydrochloride Chemical Structure

Promethazine-d₄ hydrochloride Chemical Structure

CAS No. : 1173018-74-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Promethazine-d₄ hydrochloride:

Promethazine hydrochloride In-stock
Promethazine-d₄ Get quote

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

H₁ Receptor

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

324.90

Formula

C₁₇H₁₇D₄ClN₂S

CAS No.

1173018-74-0

Unlabeled CAS

58-33-3

Appearance

Solid

Color

Off-white to yellow

SMILES

CN(C)C(C)CN1C2=C([2H])C=C([2H])C=C2SC3=CC([2H])=CC([2H])=C31.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (307.79 mM; Need ultrasonic)

DMSO : 50 mg/mL (153.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0779 mL	15.3894 mL	30.7787 mL
5 mM	0.6156 mL	3.0779 mL	6.1557 mL
10 mM	0.3078 mL	1.5389 mL	3.0779 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505. [Content Brief]

[3]. Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56. [Content Brief]

[4]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9. [Content Brief]

[5]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.0779 mL	15.3894 mL	30.7787 mL	76.9468 mL
	5 mM	0.6156 mL	3.0779 mL	6.1557 mL	15.3894 mL
	10 mM	0.3078 mL	1.5389 mL	3.0779 mL	7.6947 mL
	15 mM	0.2052 mL	1.0260 mL	2.0519 mL	5.1298 mL
	20 mM	0.1539 mL	0.7695 mL	1.5389 mL	3.8473 mL
	25 mM	0.1231 mL	0.6156 mL	1.2311 mL	3.0779 mL
	30 mM	0.1026 mL	0.5130 mL	1.0260 mL	2.5649 mL
	40 mM	0.0769 mL	0.3847 mL	0.7695 mL	1.9237 mL
	50 mM	0.0616 mL	0.3078 mL	0.6156 mL	1.5389 mL
	60 mM	0.0513 mL	0.2565 mL	0.5130 mL	1.2824 mL
	80 mM	0.0385 mL	0.1924 mL	0.3847 mL	0.9618 mL
	100 mM	0.0308 mL	0.1539 mL	0.3078 mL	0.7695 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.