Propargyl-PEG4-GGFG-DXd

Cat. No.: HY-156755 Purity: 99.99%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for ADC. Propargyl-PEG4-GGFG-DXd contains a ADC linker and a DNA topoisomerase I inhibitor DXd (HY-13631D).

For research use only. We do not sell to patients.

Propargyl-PEG4-GGFG-DXd Chemical Structure

CAS No. : 2762518-94-3

Size	Price	Stock	Quantity
5 mg	USD 490	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 790	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for ADC. Propargyl-PEG4-GGFG-DXd contains a ADC linker and a DNA topoisomerase I inhibitor DXd (HY-13631D)^[1].

Molecular Weight

1083.12

Formula

C₅₄H₆₃FN₈O₁₅

CAS No.

2762518-94-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

C#CCOCCOCCOCCOCCC(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(NCOCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (92.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9233 mL	4.6163 mL	9.2326 mL
5 mM	0.1847 mL	0.9233 mL	1.8465 mL
10 mM	0.0923 mL	0.4616 mL	0.9233 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (248 KB) HNMR (434 KB) RP-HPLC (255 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

References

[1]. Yang, Yi, et al. Protein conjugates with multiple payloads and methods for making the same. Patent. WO2023141855.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9233 mL	4.6163 mL	9.2326 mL	23.0815 mL
	5 mM	0.1847 mL	0.9233 mL	1.8465 mL	4.6163 mL
	10 mM	0.0923 mL	0.4616 mL	0.9233 mL	2.3081 mL
	15 mM	0.0616 mL	0.3078 mL	0.6155 mL	1.5388 mL
	20 mM	0.0462 mL	0.2308 mL	0.4616 mL	1.1541 mL
	25 mM	0.0369 mL	0.1847 mL	0.3693 mL	0.9233 mL
	30 mM	0.0308 mL	0.1539 mL	0.3078 mL	0.7694 mL
	40 mM	0.0231 mL	0.1154 mL	0.2308 mL	0.5770 mL
	50 mM	0.0185 mL	0.0923 mL	0.1847 mL	0.4616 mL
	60 mM	0.0154 mL	0.0769 mL	0.1539 mL	0.3847 mL
	80 mM	0.0115 mL	0.0577 mL	0.1154 mL	0.2885 mL