2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Propargyl-PEG4-GGFG-DXd

Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for ADC. Propargyl-PEG4-GGFG-DXd contains a ADC linker and a DNA topoisomerase I inhibitor DXd (HY-13631D).

For research use only. We do not sell to patients.

Propargyl-PEG4-GGFG-DXd Chemical Structure

Propargyl-PEG4-GGFG-DXd Chemical Structure

CAS No. : 2762518-94-3

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1 mg USD 190 In-stock
5 mg USD 490 In-stock
10 mg USD 790 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Propargyl-PEG4-GGFG-DXd Related Antibodies

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Description

Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for ADC. Propargyl-PEG4-GGFG-DXd contains a ADC linker and a DNA topoisomerase I inhibitor DXd (HY-13631D)[1].

Molecular Weight

1083.12

Formula

C54H63FN8O15
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C#CCOCCOCCOCCOCCC(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(NCOCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (92.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9233 mL 4.6163 mL 9.2326 mL
5 mM 0.1847 mL 0.9233 mL 1.8465 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.99%

COA (248 KB) HNMR (434 KB) RP-HPLC (255 KB) LCMS (102 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9233 mL 4.6163 mL 9.2326 mL 23.0815 mL
5 mM 0.1847 mL 0.9233 mL 1.8465 mL 4.6163 mL
10 mM 0.0923 mL 0.4616 mL 0.9233 mL 2.3081 mL
15 mM 0.0616 mL 0.3078 mL 0.6155 mL 1.5388 mL
20 mM 0.0462 mL 0.2308 mL 0.4616 mL 1.1541 mL
25 mM 0.0369 mL 0.1847 mL 0.3693 mL 0.9233 mL
30 mM 0.0308 mL 0.1539 mL 0.3078 mL 0.7694 mL
40 mM 0.0231 mL 0.1154 mL 0.2308 mL 0.5770 mL
50 mM 0.0185 mL 0.0923 mL 0.1847 mL 0.4616 mL
60 mM 0.0154 mL 0.0769 mL 0.1539 mL 0.3847 mL
80 mM 0.0115 mL 0.0577 mL 0.1154 mL 0.2885 mL
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Propargyl-PEG4-GGFG-DXd Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG4-GGFG-DXd2762518-94-3Drug-Linker Conjugates for ADCDrug-Linker ConjugatesADCMMAEInhibitorinhibitorinhibit

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