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  4. PROTAC eDHFR Degrader-1

PROTAC eDHFR Degrader-1 is a PROTAC that is effective degradation of eDHFR-YFP, various POIs-including YFP and Luciferase.

For research use only. We do not sell to patients.

PROTAC eDHFR Degrader-1 Chemical Structure

PROTAC eDHFR Degrader-1 Chemical Structure

CAS No. : 2849442-92-6

Size Price Stock Quantity
5 mg USD 610 In-stock
10 mg USD 980 In-stock
25 mg USD 1960 In-stock
50 mg USD 3100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

PROTAC eDHFR Degrader-1 Related Antibodies

Top Publications Citing Use of Products

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Description

PROTAC eDHFR Degrader-1 is a PROTAC that is effective degradation of eDHFR-YFP, various POIs-including YFP and Luciferase[1].

Molecular Weight

748.78

Formula

C36H44N8O10
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=C(CC2=CC(OC)=C(OCCCC(NCCOCCOCCNC3=CC=CC(C(N4C5CCC(NC5=O)=O)=O)=C3C4=O)=O)C(OC)=C2)C=NC(N)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (133.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3355 mL 6.6775 mL 13.3551 mL
5 mM 0.2671 mL 1.3355 mL 2.6710 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3355 mL 6.6775 mL 13.3551 mL 33.3876 mL
5 mM 0.2671 mL 1.3355 mL 2.6710 mL 6.6775 mL
10 mM 0.1336 mL 0.6678 mL 1.3355 mL 3.3388 mL
15 mM 0.0890 mL 0.4452 mL 0.8903 mL 2.2258 mL
20 mM 0.0668 mL 0.3339 mL 0.6678 mL 1.6694 mL
25 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.3355 mL
30 mM 0.0445 mL 0.2226 mL 0.4452 mL 1.1129 mL
40 mM 0.0334 mL 0.1669 mL 0.3339 mL 0.8347 mL
50 mM 0.0267 mL 0.1336 mL 0.2671 mL 0.6678 mL
60 mM 0.0223 mL 0.1113 mL 0.2226 mL 0.5565 mL
80 mM 0.0167 mL 0.0835 mL 0.1669 mL 0.4173 mL
100 mM 0.0134 mL 0.0668 mL 0.1336 mL 0.3339 mL
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PROTAC eDHFR Degrader-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC eDHFR Degrader-12849442-92-6PROTAC eDHFR Degrader1PROTAC eDHFR Degrader 1PROTACsPROTAC eDHFR-YFP Degrader-1Inhibitorinhibitorinhibit

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