2. JAK/STAT Signaling PROTAC Protein Tyrosine Kinase/RTK
  3. EGFR PROTACs
  4. PROTAC EGFR degrader 8

PROTAC EGFR degrader 8 (T-184) is a PROTAC EGFR degrader. PROTAC EGFR degrader 8 degrades EGFR in HCC827 cell with a DC50 of 15.56 nM. PROTAC EGFR degrader 8 inhibits H1975, PC-9, HCC827 cell growth with IC50s of 7.72 nM, 121.9 nM, 14.21 nM. PROTAC EGFR degrader 8 can be used for research of cancer, especially NSCLC.

For research use only. We do not sell to patients.

PROTAC EGFR degrader 8 Chemical Structure

PROTAC EGFR degrader 8 Chemical Structure

CAS No. : 2925923-46-0

Size Price Stock Quantity
5 mg USD 510 In-stock
10 mg USD 765 In-stock
25 mg USD 1531 In-stock
50 mg USD 2297 In-stock
100 mg USD 3446 In-stock
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Based on 1 publication(s) in Google Scholar

PROTAC EGFR degrader 8 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC EGFR degrader 8 (T-184) is a PROTAC EGFR degrader. PROTAC EGFR degrader 8 degrades EGFR in HCC827 cell with a DC50 of 15.56 nM. PROTAC EGFR degrader 8 inhibits H1975, PC-9, HCC827 cell growth with IC50s of 7.72 nM, 121.9 nM, 14.21 nM. PROTAC EGFR degrader 8 can be used for research of cancer, especially NSCLC[1].

Molecular Weight

796.32

Formula

C40H46ClN11O5
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C1=C(NC2=NC(NC3=CC=C(N4CCN(CC4)C(CN5CCN(CC5)C6=CC=C(NC7C(NC(CC7)=O)=O)C=C6)=O)C=C3OC)=NC=C2Cl)C=CC=C1)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (125.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2558 mL 6.2789 mL 12.5578 mL
5 mM 0.2512 mL 1.2558 mL 2.5116 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2558 mL 6.2789 mL 12.5578 mL 31.3944 mL
5 mM 0.2512 mL 1.2558 mL 2.5116 mL 6.2789 mL
10 mM 0.1256 mL 0.6279 mL 1.2558 mL 3.1394 mL
15 mM 0.0837 mL 0.4186 mL 0.8372 mL 2.0930 mL
20 mM 0.0628 mL 0.3139 mL 0.6279 mL 1.5697 mL
25 mM 0.0502 mL 0.2512 mL 0.5023 mL 1.2558 mL
30 mM 0.0419 mL 0.2093 mL 0.4186 mL 1.0465 mL
40 mM 0.0314 mL 0.1570 mL 0.3139 mL 0.7849 mL
50 mM 0.0251 mL 0.1256 mL 0.2512 mL 0.6279 mL
60 mM 0.0209 mL 0.1046 mL 0.2093 mL 0.5232 mL
80 mM 0.0157 mL 0.0785 mL 0.1570 mL 0.3924 mL
100 mM 0.0126 mL 0.0628 mL 0.1256 mL 0.3139 mL
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PROTAC EGFR degrader 8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EGFR degrader 82925923-46-0PROTAC EGFR degrader8PROTAC EGFR degrader-8EGFRPROTACsEpidermal growth factor receptorErbB-1HER1CancerNSCLCH1975PC-9HCC827Inhibitorinhibitorinhibit

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