2. Neuronal Signaling
  3. α-synuclein Tau Protein
  4. PROTAC α-synuclein degrader 6

PROTAC α-synuclein degrader 6 

Cat. No.: HY-157839 Purity: 99.04%
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PROTAC α-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with EC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-synuclein degrader 6 plays an important role in neurodegenerative diseases (NDs) research.

For research use only. We do not sell to patients.

PROTAC α-synuclein degrader 6 Chemical Structure

PROTAC α-synuclein degrader 6 Chemical Structure

CAS No. : 3032208-24-2

Size Price Stock Quantity
5 mg USD 255 In-stock
10 mg USD 405 In-stock
25 mg USD 810 Get quote
50 mg USD 1300 Get quote
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Based on 1 publication(s) in Google Scholar

PROTAC α-synuclein degrader 6 Related Antibodies

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Description

PROTAC α-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with EC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-synuclein degrader 6 plays an important role in neurodegenerative diseases (NDs) research[1].

Molecular Weight

729.80

Formula

C37H39N5O9S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC4=CC=C(C(S5)=NC6=C5C=C(C)C=C6)C=C4)=O)=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (137.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3702 mL 6.8512 mL 13.7024 mL
5 mM 0.2740 mL 1.3702 mL 2.7405 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3702 mL 6.8512 mL 13.7024 mL 34.2560 mL
5 mM 0.2740 mL 1.3702 mL 2.7405 mL 6.8512 mL
10 mM 0.1370 mL 0.6851 mL 1.3702 mL 3.4256 mL
15 mM 0.0913 mL 0.4567 mL 0.9135 mL 2.2837 mL
20 mM 0.0685 mL 0.3426 mL 0.6851 mL 1.7128 mL
25 mM 0.0548 mL 0.2740 mL 0.5481 mL 1.3702 mL
30 mM 0.0457 mL 0.2284 mL 0.4567 mL 1.1419 mL
40 mM 0.0343 mL 0.1713 mL 0.3426 mL 0.8564 mL
50 mM 0.0274 mL 0.1370 mL 0.2740 mL 0.6851 mL
60 mM 0.0228 mL 0.1142 mL 0.2284 mL 0.5709 mL
80 mM 0.0171 mL 0.0856 mL 0.1713 mL 0.4282 mL
100 mM 0.0137 mL 0.0685 mL 0.1370 mL 0.3426 mL
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PROTAC α-synuclein degrader 6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC α-synuclein degrader 63032208-24-2α-synucleinTau Proteinα-SynMPTP-induced PD mouse model neurodegenerative diseasesInhibitorinhibitorinhibit

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