From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. We are sorry for the inconvenience. Please arrange your schedule properly.
Absent in melanoma 2 (AIM2)-like receptors (ALRs) are a family of pathogen recognition receptors (PRRs) involved in cytosolic and nuclear pathogen DNA recognition. Structurally, ALRs are characterized by a Pyrin signaling domain and a DNA-binding HIN domain. Interestingly, the ALR locus is highly variable in different species, For example, humans have 4 ALRs (AIM2, IFI16, PYHIN1, and MNDA), while mice have 13 or 14, including Aim2, p202, p203, p204, p205, p207, pyhin1, and cows have a single ALR. The best characterized ALR is AIM2 (absent in melanoma 2), the intracellular DNA sensor which signals via the adaptor protein ASC (Apoptosis-associated speck-like protein containing a CARD), to activate the inflammasome, a key arm of the innate immune system.
NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-Flag, N-8*His labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag), has molecular weight of 25-40 kDa.
CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (HEK293, His) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-6*His labeled tag.
CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.
Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2
Human
Sf9 insect cells
AIM2 Protein, a member of the IFI20X/IFI16 family, exhibits potential regulatory functions in cell proliferation and tumorigenic reversion. Induced by interferon-gamma, AIM2 plays a key role in immune responses. Notably expressed in tissues like lymph node and appendix, AIM2 is a significant player in diverse cellular processes and immune-related functions. AIM2 Protein, Human (sf9, GST) is the recombinant human-derived AIM2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AIM2 Protein, Human (sf9, GST) is 343 a.a., with molecular weight of ~65.2 kDa.
NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-hFc, N-Flag labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag), has molecular weight of 55-65 kDa.
NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with C-mFc labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc), has molecular weight of 70-90 kDa.
The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293 , with N-His, N-Avi labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi), has molecular weight of 33-48 kDa.
NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-His, N-Avi labeled tag. NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 33-48 kDa.
The NKG2C/CD159c protein is an immune-activating receptor that plays a critical role in self-non-self discrimination. It cooperates with KLRD1 to recognize non-classical MHC class Ib HLA-E loaded with HLA-G peptides, affecting adaptive NK cell function and maternal-fetal tolerance. NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293 , with N-His, N-Avi labeled tag. NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi), has molecular weight of 30-50 kDa.
CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-Avi, N-His labeled tag.
NKG2C/CD159c Protein, an immune activating receptor, crucially contributes to self-nonself discrimination. Partnering with KLRD1, it recognizes non-classical MHC class Ib HLA-E loaded with peptides from HLA-G, impacting adaptive NK cell functions and maternal-fetal tolerance. NKG2C/CD159c regulates terminally differentiated cytotoxic lymphocytes, particularly in adaptive NK cell responses to viral infection. Upon binding to HLA-E-peptide complexes, it transmits intracellular signals via TYROBP/DAP12, initiating cell activation. The multifaceted interactions highlight its essential role in immune responses and self-tolerance mechanisms. NKG2C-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293, with C-Avi, N-His labeled tag. NKG2C-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 25-35 kDa.
The NKG2C/CD159c protein is an immune-activating receptor that plays a critical role in self-non-self discrimination. It cooperates with KLRD1 to recognize non-classical MHC class Ib HLA-E loaded with HLA-G peptides, affecting adaptive NK cell function and maternal-fetal tolerance. NKG2C-CD94 Heterodimer Protein, Cynomolgus (HEK293, His-Flag) is a recombinant protein dimer complex containing cynomolgus-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293 , with N-His, C-Flag labeled tag. NKG2C-CD94 Heterodimer Protein, Cynomolgus (HEK293, His-Flag), has molecular weight of 35-45 kDa.
AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2
Human
E. coli
AIM2 protein is a key sensor in the AIM2 inflammasome, which can activate the inflammasome in response to cytoplasmic dsDNA, thereby inducing pyroptosis. This complex is triggered by pathogens or injury signals and plays a critical role in innate immunity and inflammation. AIM2 Protein, Human is the recombinant human-derived AIM2 protein, expressed by E. coli , with tag free. The total length of AIM2 Protein, Human is 200 a.a., .
AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2
Human
E. coli
AIM2 protein is a key sensor in the AIM2 inflammasome, which can activate the inflammasome in response to cytoplasmic dsDNA, thereby inducing pyroptosis. This complex is triggered by pathogens or injury signals and plays a critical role in innate immunity and inflammation. AIM2 Protein, Human (His) is the recombinant human-derived AIM2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of AIM2 Protein, Human (His) is 200 a.a., .
