1. Recombinant Proteins
  2. Receptor Proteins
  3. Pattern Recognition Receptors
  4. AIM2-like receptors
  5. Absent In Melanoma 2 (AIM2)
  6. AIM2 Protein, Human (sf9, GST)

AIM2 Protein, Human (sf9, GST)

Cat. No.: HY-P72816
Handling Instructions

AIM2 Protein, a member of the IFI20X/IFI16 family, exhibits potential regulatory functions in cell proliferation and tumorigenic reversion. Induced by interferon-gamma, AIM2 plays a key role in immune responses. Notably expressed in tissues like lymph node and appendix, AIM2 is a significant player in diverse cellular processes and immune-related functions. AIM2 Protein, Human (sf9, GST) is the recombinant human-derived AIM2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AIM2 Protein, Human (sf9, GST) is 343 a.a., with molecular weight of ~65.2 kDa.

For research use only. We do not sell to patients.

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Description

AIM2 Protein, a member of the IFI20X/IFI16 family, exhibits potential regulatory functions in cell proliferation and tumorigenic reversion. Induced by interferon-gamma, AIM2 plays a key role in immune responses. Notably expressed in tissues like lymph node and appendix, AIM2 is a significant player in diverse cellular processes and immune-related functions. AIM2 Protein, Human (sf9, GST) is the recombinant human-derived AIM2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AIM2 Protein, Human (sf9, GST) is 343 a.a., with molecular weight of ~65.2 kDa.

Background

AIM2 Protein, a member of the IFI20X/IFI16 family, is implicated in tumorigenic reversion and has potential regulatory functions in cell proliferation. The expression of AIM2 is induced by interferon-gamma, emphasizing its involvement in immune responses. With biased expression observed in tissues such as lymph node (RPKM 9.4), appendix (RPKM 5.0), and five other tissues, AIM2 stands out as a key player in diverse cellular processes and immune-related functions.

Species

Human

Source

Sf9 insect cells

Tag

N-GST

Accession

O14862/NP_004824.1 (M1-T343)

Gene ID
Molecular Construction
N-term
GST
AIM2 (M1-T343)
Accession # NP_004824.1
C-term
Synonyms
Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2
AA Sequence

MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT

Molecular Weight

Approximately 65.2 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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AIM2 Protein, Human (sf9, GST)
Cat. No.:
HY-P72816
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