2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interferon & Receptors
  5. IFN-alpha
  6. IFN-alpha 1

IFN-alpha 1

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IFN-alpha 1 (IFNA1; IFN-α1), belongs to the alpha/beta interferon family, is produced by macrophages with antiviral activities[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively[2].
IFNs binds to one of three type-specific receptors, which leads to the activation of JAK1 and TYK2[3]. This signal transduction results in phosphorylation of STAT1 and STAT2 and eventually in an association with IFN regulatory factor 9 (IRF9) and formation of the IFN-stimulated gene factor 3 (ISGF3) complex. Thus the ISGF3 complex induces transcription of IFN-stimulated genes (ISGs), with subsequent immunomodulatory effects on both innate and adaptive immune responses[4]. The interactions of type I IFN with the immune system is important for the generation of a durable antitumor response through its effects on dendritic cells (DC)[5].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P700089AF
    Animal-Free IFN-alpha 1/IFNA13 Protein, Human (His)

    Leukocyte Interferon; IFNA1; B cell Interferon; Type I Interferon; Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1a; IFNA13

    		Human E. coli
    IFN-alpha 1a/IFNA1 Protein, produced by macrophages, demonstrates robust antiviral activities. It stimulates essential enzymes—a protein kinase and an oligoadenylate synthetase—contributing to the intricate molecular response that fortifies the host's immune defenses against viral threats. Animal-Free IFN-alpha 1/IFNA13 Protein, Human (His) is the recombinant human-derived animal-FreeIFN-alpha 1a/IFNA1 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IFN-alpha 1/IFNA13 Protein, Human (His) is 166 a.a., with molecular weight of ~20.19 kDa.
  • HY-P700183AF
    Animal-Free IFN alpha 1/IFNA1 Protein, Mouse (His)

    Interferon alpha 1a; Ifa; Ifa8; IFNA

    		Mouse E. coli
    IFN alpha 1a Protein, synthesized by macrophages, exhibits robust antiviral activities by stimulating key enzymes—a protein kinase and an oligoadenylate synthetase. This orchestrated molecular response enhances the host's immune defenses against viral threats. Animal-Free IFN alpha 1/IFNA1 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIFN alpha 1a protein, expressed by E. coli , with N-His labeled tag.
  • HY-P701053
    IFN-alpha 1/IFNA1 Protein, Mouse (HEK293, hFc)

    Interferon alpha-1/13; IFN-alpha-1/13; Interferon alpha-D; LeIF D; IFNalpha 1; IFN alpha1; IFNA1; IFN-alpha-1; Interferon alpha 1

    		Mouse HEK293
    IFN alpha 1a Protein, synthesized by macrophages, exhibits robust antiviral activities by stimulating key enzymes—a protein kinase and an oligoadenylate synthetase. This orchestrated molecular response enhances the host's immune defenses against viral threats. IFN-alpha 1/IFNA1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived IFN-alpha 1/IFNA1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IFN-alpha 1/IFNA1 Protein, Mouse (HEK293, hFc) is 166 a.a., with molecular weight of 50-60 kDa.
  • HY-P70241
    IFN-alpha 1/IFNA13 Protein, Human (HEK293, His)

    rHuInterferon alpha-1, His; Interferon alpha-1/13; IFN-alpha-1/13; Interferon alpha-D; LeIF D; IFNA1; IFNA13

    		Human HEK293
    IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA13 Protein, Human (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag.
  • HY-P74864
    IFN-alpha 1/IFNA1 Protein, Rat (HEK293, His)

    Interferon alpha-1; IFN-alpha-1; IFNA1

    		Rat HEK293
    IFN-alpha 1/IFNA1 Protein, Rat (HEK293, His) is the recombinant rat-derived IFN-alpha 1/IFNA1, expressed by HEK293 , with C-His labeled tag. ,
  • HY-P74866
    IFN-alpha 1/IFNA1 Protein, Mouse (P.pastoris, His)

    IFNA1; IFNalpha 1; IFN-alpha 1

    		Mouse P. pastoris
    IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA1 Protein, Mouse (P.pastoris, His) is produced in P.pastoris yeast cells with a C-Terminal His-tag.
  • HY-P74864A
    IFN-alpha 1/IFNA1 Protein, Rat (HEK293, C-His)

    Interferon alpha-1; IFN-alpha-1; IFNA1

    		Rat HEK293
    IFN-alpha 1/IFNA1 Protein, Rat (HEK293, C-His) is the recombinant rat-derived IFN-alpha 1/IFNA1, expressed by HEK293 , with C-6*His labeled tag. ,
  • HY-P73245
    IFN-alpha 1/IFNA13 Protein, Human (P.pastoris, His)

    Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13

    		Human P. pastoris
    IFN-alpha 13 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA13 Protein, Human (P.pastoris, His) is produced in P.pastoris yeast cells with a C-Terminal His tag.
  • HY-P74865
    IFN-alpha 1/IFNA1 Protein, Rat (HEK293, hFc)

    Interferon alpha-1; IFN-alpha-1; IFNA1

    		Rat HEK293
    IFN-alpha 1/IFNA1 Protein, Rat (HEK293, hFc) is the recombinant rat-derived IFN-alpha 1/IFNA1, expressed by HEK293 , with C-hFc labeled tag. ,
Cat. No. Product Name Effect Purity