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  4. Interleukin & Receptors Neurotrophic Factors
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  6. IL-1 alpha

IL-1 alpha

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IL-1 alpha is a major agonist of IL-1 and also is a pro-inflammatory cytokine. IL-1 alpha acts as an ‘alarmin’ and as a primum movens of tissue inflammation[1]. IL-1 alpha inhibits differentiation of preadipocytes and lipid accumulation[2]. IL-1 alpha induces apoptosis and inhibits the osteoblast differentiation[3]. IL-1 alpha trigger inflammation in a pathway initiated through Myd88 activation and culminated in NF-κB–induced transcription of inflammatory genes[4].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73145
    IL-1 alpha Protein, Human (HEK293)

    IL-1α; Hematopoietin-1; IL1A; IL1F1; IL-1 alpha

    		Human HEK293
    IL-1 alpha is a ubiquitous and pivotal pro-inflammatory cytokine. IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1 alpha mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. IL-1 alpha protein, Human (HEK293) is a recombinant protein consisting of 159 amino acids (S113-A271) and is produced by HEK293 cells.
  • HY-P700095AF
    Animal-Free IL-1 alpha Protein, Human (His)

    Hematopoietin-1; Lymphocyte-Activating Factor (LAF); Endogenous Pyrogen (EP); IL1A; IL1F1

    		Human E. coli
    IL-1 alpha protein is located in cells and is a key cytokine connecting innate immunity and adaptive immunity. After binding to IL1R1 through IL1RAP, it forms a high-affinity receptor complex, initiates a signaling cascade with adapter molecules such as MYD88, IRAK1 or IRAK4, and activates the NF-kappa-B and MAPK pathways. Animal-Free IL-1 alpha Protein, Human (His) is the recombinant human-derived animal-FreeIL-1 alpha protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-1 alpha Protein, Human (His) is 159 a.a., with molecular weight of ~18.99 kDa.
  • HY-P7027
    IL-1 alpha Protein, Human

    rHuIL-1α; Hematopoietin-1; IL1A; IL1F1; IL-1 alpha

    		Human E. coli
    IL-1 alpha is a ubiquitous and pivotal pro-inflammatory cytokine. IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1 alpha mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. IL-1 alpha protein, Human is a recombinant protein consisting of 159 amino acids (S113-A271) and is produced by E. coli.
  • HY-P7096
    IL-1 alpha Protein, Rat (CHO)

    rRtIL-1α; Hematopoietin-1; IL1A; IL1F1; IL-1 alpha

    		Rat CHO
    IL-1 alpha is a ubiquitous and pivotal pro-inflammatory cytokine. IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1 alpha mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways.
  • HY-P7072
    IL-1 alpha Protein, Mouse

    rMuIL-1α; Hematopoietin-1; IL1A; IL1F1; IL-1 alpha

    		Mouse E. coli
    IL-1 alpha is a ubiquitous and pivotal pro-inflammatory cytokine. IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1 alpha mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. IL-1 alpha protein, Mouse is a recombinant protein consisting of 156 amino acids (S115-A270) and is produced by E. coli.
  • HY-P72380
    IL-1 alpha Protein, Human (Biotinylated, HEK293, Avi)

    Interleukin-1 Alpha; IL-1 Alpha; Hematopoietin-1; IL1A; IL1F1; IL-1a

    		Human E. coli
    IL-1 alpha is a ubiquitous and pivotal pro-inflammatory cytokine. IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1 alpha mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. IL-1 alpha protein, Human (Biotinylated, HEK293, Avi) is a biotinylated recombinant protein with Avi label that consists of 159 amino acids (S113-A271) and is produced by E. coli.
  • HY-P700186AF
    Animal-Free IL-1 alpha Protein, Mouse (His)

    Hematopoietin-1; Lymphocyte-Activating Factor (LAF); Endogenous Pyrogen (EP); Leukocyte

    		Mouse E. coli
    IL-1 alpha protein is an important cytokine found intracellularly in non-hematopoietic cells that bridges innate and adaptive immunity. Binds to IL1R1 and IL1RAP to form a high-affinity receptor complex, initiates signaling through MYD88, IRAK1 or IRAK4, and activates the NF-kappa-B and MAPK pathways. Animal-Free IL-1 alpha Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-1 alpha protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-1 alpha Protein, Mouse (His) is 156 a.a., with molecular weight of ~18.93 kDa.
  • HY-P71866
    IL-1 alpha Protein, Rhesus macaque

    IL1A; Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1

    		Rhesus Macaque E. coli
    IL-1 alpha, a cytokine present in non-hematopoietic cells, links innate and adaptive immunity. Binding to its receptor IL1R1, IL-1 alpha forms a receptor complex, activating signaling pathways involving MYD88, IRAK1, and IRAK4. It activates NF-kappa-B and MAPK pathways. Released during cell death, IL-1 alpha induces inflammation, senses DNA damage, and interacts with TMED10, IL1R1, and S100A13 for secretion and plasma membrane translocation. IL-1 alpha Protein, Rhesus macaque is the recombinant Rhesus Macaque-derived IL-1 alpha protein, expressed by E. coli , with tag free. The total length of IL-1 alpha Protein, Rhesus macaque is 159 a.a., with molecular weight of ~18.1 kDa.
  • HY-P70454G
    GMP IL-1 alpha Protein, Human

    Interleukin-1 Alpha; IL-1 Alpha; Hematopoietin-1; IL1A; IL1F1

    		Human E. coli
    IL-1 alpha is a ubiquitous and pivotal pro-inflammatory cytokine. IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1 alpha mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. GMP IL-1 alpha Protein, Human is a recombinant protein consisting of 153 amino acids (A117-S269) and is produced by E. coli.
  • HY-P72572
    IL-1 alpha Protein, Rat

    Interleukin-1 alpha; IL-1 alpha; Il1a

    		Rat E. coli
    IL-1 alpha is a ubiquitous and pivotal pro-inflammatory cytokine. IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1 alpha mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. IL-1 alpha protein, Rat is a recombinant protein consisting of 156 amino acids (S115-S270) and is produced by E. coli.
  • HY-P700290
    IL-1 alpha Protein, Human (HEK293, Fc)

    Interleukin-1 Alpha; IL-1 Alpha; Hematopoietin-1; IL1A; IL1F1;

    		Human HEK293
    IL-1 alpha protein is located in cells and is a key cytokine connecting innate immunity and adaptive immunity. After binding to IL1R1 through IL1RAP, it forms a high-affinity receptor complex, initiates a signaling cascade with adapter molecules such as MYD88, IRAK1 or IRAK4, and activates the NF-kappa-B and MAPK pathways. IL-1 alpha Protein, Human (HEK293, Fc) is the recombinant human-derived IL-1 alpha protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-1 alpha Protein, Human (HEK293, Fc) is 159 a.a., with molecular weight of 54 kDa.
  • HY-P700739
    IL-1 alpha Protein, Cynomolgus (HEK293, His)

    Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1; IL-1 ALPHA; IL1α; IL-1A; IL1

    		Cynomolgus HEK293
    IL-1 alpha, found in non-hematopoietic cells, connects innate and adaptive immunity. Binding to IL1R1, it activates signaling pathways involving MYD88, IRAK1, and IRAK4, leading to NF-kappa-B and MAPK pathway activation. Released during cell death, IL-1 alpha induces inflammation, senses DNA damage, and interacts with TMED10, IL1R1, and S100A13 for secretion and plasma membrane translocation. IL-1 alpha Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-1 alpha protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-1 alpha Protein, Cynomolgus (HEK293, His) is 159 a.a., with molecular weight of 25-35 kDa.
  • HY-P700242AF
    Animal-Free IL-1 alpha/IL-1F1 Protein, Pig (His)

    Interleukin-1 alpha; IL1A; IL-1 alpha; Interleukin 1 alpha

    		Pig E. coli
    The IL-1α/IL-1F1 protein is found intracellularly in most non-hematopoietic cells and plays a crucial role in mediating inflammation and linking innate and adaptive immunity. IL1RAP binds to IL1R1 to form a high-affinity receptor complex that activates cascades and pathways. Animal-Free IL-1 alpha/IL-1F1 Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-1 alpha/IL-1F1 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-1 alpha/IL-1F1 Protein, Pig (His) is 158 a.a., with molecular weight of ~19.02 kDa.
Cat. No. Product Name Effect Purity