2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-17 Receptor
  6. IL-17RC

IL-17RC

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IL-17RC (Interleukin 17 receptor C), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed on a variety of nonhematopoietic cell types, and plays a role in inflammatory diseases, including autoimmunity and certain cancers. IL-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17R complex, comprised of the IL-17RA and IL-17RC subunits. The expression profile and tissue distribution of IL-17RC suggest that the gene regulation of IL-17RC differs considerably from IL-17RA[1].
IL-17RA co-immunoprecipitates with IL-17RC in a ligand-dependent manner, raising the possibility that the ligand-dependent loss of FRET between IL-17RA subunits results from oligomerization with IL-17RC. Consistent with this, IL-17RC also forms large, multimeric complexes consistent with oligomerization with IL-17RA. IL-17RC forms heterodimers with IL-17RA to mediate IL-17A and IL-17F signals in mouse stromal cells and human gastric adenocarcinoma AGS cells and synoviocytes. Specific overexpression of IL-17RC protects prostate cancer cell lines from TNFα-induced apoptosis. IL-17RC also contributes to autoimmune disease pathogenesis[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72580
    IL-17RC Protein, Human (HEK293, Fc)

    Interleukin-17 receptor C; IL-17 receptor C; IL17RC; IL17Rhom; IL-17RL; ZcytoR14

    		Human HEK293
    IL-17RC (Interleukin 17 receptor C), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed on a variety of nonhematopoietic cell types, and plays a role in inflammatory diseases, including autoimmunity and certain cancers. IL-17RC associates with IL-17RA to form a signaling receptor complex for IL-17A and IL-17F.IL-17RC Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag.
  • HY-P75837
    IL-17RC Protein, Human (sf9, His)

    Interleukin-17 receptor C; IL-17 receptor C; IL17RC; IL17Rhom; IL-17RL; ZcytoR14

    		Human Sf9 insect cells
    IL-17RC (Interleukin 17 receptor C), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed on a variety of nonhematopoietic cell types, and plays a role in inflammatory diseases, including autoimmunity and certain cancers. IL-17RC associates with IL-17RA to form a signaling receptor complex for IL-17A and IL-17F. IL-17RC Protein, Human (sf9, His) is produced in Sf9 insect cells with a C-Terminal His-tag.
Cat. No. Product Name Effect Purity