2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CXC Chemokines
  6. SR-PSOX/CXCL16

SR-PSOX/CXCL16

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CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 is expressed in soluble or transmembrane forms and can be observed in many cell types, including inflammatory cells (such as macrophages, neutrophils, dendritic cells and monocytes) and non-inflammatory cells (such as lung epithelial cells and renal cells). CXCL16 plays important roles both in the natural immune barrier and in the occurrence and development of autoimmune diseases[1][2].
CXCL16 is primarily expressed on the surface of antigen-presenting cells (APCs) and consists of a chemokine domain (∼89 amino acids), a mucin-type stalk (∼110 amino acids), a single-pass transmembrane domain (∼20 amino acids), and a cytoplasmic tail (∼27 amino acids). CXCL16 is the only ligand of the CXCR6 receptor. Soluble CXCL16 induces the migration of CXCR6+ cells (including Th1 cells, NK cells and activated CD8 + T-cells), M2-macrophage infiltration, interactions between APC and CD8 + T-cells, the cellular immune response and inflammatory response, and the development of thymocytes. Membrane-bound CXCL16 can promote the adhesion of CXCR6+ cells. CXCL16 specifically binds oxidized low-density lipoprotein (OxLDL), leading to its internalization and degradation. CXCL16 may play important roles in the formation of atherosclerotic lesions. CXCL16 on macrophages and dendritic cells mediates the adhesion and phagocytosis of bacteria, such as Escherichia coli and Staphylococcus aureus, and bacterial recognition is mediated by the chemokine domain of CXCL16[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72961
    CXCL16 Protein, Human (HEK293, His)

    C-X-C motif chemokine 16; SR-PSOX; Srpsox; SCYB16; CXCL16

    		Human HEK293
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Human (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 176 amino acids (N49-T224).
  • HY-P7151
    CXCL16 Protein, Mouse

    rMuCXCL16; C-X-C motif chemokine 16; SR-PSOX; Srpsox

    		Mouse E. coli
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Mouse is produced in E. coli, and consists of 88 amino acids (N27-P114).
  • HY-P72681
    CXCL16 Protein, Mouse (HEK293, His)

    C-X-C motif chemokine 16; SR-PSOX; CXCL16; SCYB16

    		Mouse HEK293
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Mouse (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 175 amino acids (N27-W201).
  • HY-P77910
    CXCL16 Protein, Human (HEK293, Fc)

    SR-PSOX; CXCLG16; SRPSOX; CXCL16; SCYB16

    		Human HEK293
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 176 amino acids (N30-T205).
  • HY-P78288
    CXCL16 Protein, Mouse (HEK293, Fc)

    SR-PSOX; CXCLG16; SRPSOX; CXCL16; SCYB16

    		Mouse HEK293
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 175 amino acids (N27-W201).
  • HY-P700170AF
    Animal-Free CXCL16 Protein, Mouse (His)

    C-X-C motif chemokine 16; SR-PSOX; CXCL16; SCYB16

    		Mouse E. coli
    The CXCL16 protein has multiple functions, inducing chemotactic responses and initiating calcium mobilization. As a ligand, it binds to CXCR6/Bonzo and promotes cell signaling. Animal-Free CXCL16 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeCXCL16 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free CXCL16 Protein, Mouse (His) is 175 a.a., with molecular weight of ~10.74 kDa.
  • HY-P75313
    CXCL16 Protein, Rat (HEK293, His)

    C-X-C motif chemokine 16; SR-PSOX; Srpsox; SCYB16; CXCL16

    		Rat HEK293
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Rat (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag.
  • HY-P75697
    CXCL16 Protein, Canine (HEK293, His)

    C-X-C motif chemokine 16; SR-PSOX; Srpsox; SCYB16; CXCL16

    		Canine HEK293
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Canine (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 205 amino acids (M1-S205).
  • HY-P700548
    CXCL16 Protein, Mouse (His)

    C-X-C motif chemokine 16; SR-PSOX; Srpsox; SCYB16; CXCL16

    		Mouse E. coli
    The CXCL16 protein has multiple functions, inducing chemotactic responses and initiating calcium mobilization. As a ligand, it binds to CXCR6/Bonzo and promotes cell signaling. CXCL16 Protein, Mouse (His) is the recombinant mouse-derived CXCL16 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CXCL16 Protein, Mouse (His) is 172 a.a., with molecular weight of 22.7 kDa.
  • HY-P75314
    CXCL16 Protein, Rat (HEK293, Fc)

    C-X-C motif chemokine 16; SR-PSOX; Srpsox; SCYB16; CXCL16

    		Rat HEK293
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Rat (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag.
  • HY-P75696
    CXCL16 Protein, Canine (HEK293, Fc)

    C-X-C motif chemokine 16; SR-PSOX; Srpsox; SCYB16; CXCL16

    		Canine HEK293
    CXCL16, also known as SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), is one member of the ELR-negative CXC chemokine subfamily. CXCL16 is a multifunctional protein involved in various inflammatory diseases, atherosclerosis, and cancer. CXCL16 can be observed in many cell types. CXCL16 Protein, Canine (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 205 amino acids (M1-S205).
Cat. No. Product Name Effect Purity