2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. Protriptyline

Protriptyline is a potent antidepressant agent. Protriptyline inhibits AChE activity with IC50 value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease.

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Protriptyline Chemical Structure

Protriptyline Chemical Structure

CAS No. : 438-60-8

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Protriptyline Related Antibodies

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Description

Protriptyline is a potent antidepressant agent. Protriptyline inhibits AChE activity with IC50 value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease[1][2][3].

IC50 & Target[1]

AChE

0.06 mM (IC50)

In Vitro

Protriptyline (0-70 μM; 24 hours; PC3 cells) causes cytotoxicity in PC3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Protriptyline Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: PC3 cells
Concentration: 50, 60 and 70 μM
Incubation Time: 24 hours
Result: Decreased cell viability in a concentration-dependent manner.
In Vivo

Protriptyline (10 mg/kg; i.p.; for 21 days; rat model of AD) improves spatial learning and retention memory in STZ treated rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model of AD[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; for 21 days.
Result: Reduced pTau, Aβ42 and BACE-1 levels, neurodegeneration, oxidative stress and glial activation. Improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFκB and GFAP expression.
Clinical Trial
Molecular Weight

263.38

Formula

C19H21N
CAS No.
SMILES

CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Protriptyline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protriptyline438-60-8Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaalzheimersAβ Self-AssemblyAChEInhibitorinhibitorinhibit

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