2. Epigenetics TGF-beta/Smad
  3. PKC
  4. PS432

PS432 is a PKC inhibitor with IC50s of 16.9 μM (PKCι) and 18.5 μM (PKCζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lung cancer cells (NSCLCs) and tumor growth in mouse xenograft models.

For research use only. We do not sell to patients.

PS432 Chemical Structure

PS432 Chemical Structure

CAS No. : 2083630-26-4

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1 mg USD 125 In-stock
5 mg USD 380 In-stock
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Based on 1 publication(s) in Google Scholar

PS432 Related Antibodies

Top Publications Citing Use of Products

View All PKC Isoform Specific Products:

View All Isoforms
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PS432 is a PKC inhibitor with IC50s of 16.9 μM (PKCι) and 18.5 μM (PKCζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lung cancer cells (NSCLCs) and tumor growth in mouse xenograft models[1].

IC50 & Target[1]

PKCζ

18.5 μM (IC50)

PKCι

16.9 μM (IC50)

In Vitro

PS432 (25 μM; 24 h) inhibits cancer cells proliferation, with IC50s of 30.7 μM (A549) and 12.4 μM (A427) in semi solid agar medium, for example[1].
PS432 (50 μM; 12, 24, and 36 h) arrests cell cycle at G0/G1 phase in A549 lung cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PS432 Related Antibodies
In Vivo

PS432 (2.5 mg/kg; i.p.; once daily for 14 d) inhibits tumor growth in xenograft model of lung cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

494.95

Formula

C25H19ClN2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(O)C(N(C2=NC3=CC=C(C)C=C3S2)C1C4=CC=C(C5=CC=C(Cl)C=C5)O4)=O)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (202.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0204 mL 10.1020 mL 20.2041 mL
5 mM 0.4041 mL 2.0204 mL 4.0408 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0204 mL 10.1020 mL 20.2041 mL 50.5102 mL
5 mM 0.4041 mL 2.0204 mL 4.0408 mL 10.1020 mL
10 mM 0.2020 mL 1.0102 mL 2.0204 mL 5.0510 mL
15 mM 0.1347 mL 0.6735 mL 1.3469 mL 3.3673 mL
20 mM 0.1010 mL 0.5051 mL 1.0102 mL 2.5255 mL
25 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0204 mL
30 mM 0.0673 mL 0.3367 mL 0.6735 mL 1.6837 mL
40 mM 0.0505 mL 0.2526 mL 0.5051 mL 1.2628 mL
50 mM 0.0404 mL 0.2020 mL 0.4041 mL 1.0102 mL
60 mM 0.0337 mL 0.1684 mL 0.3367 mL 0.8418 mL
80 mM 0.0253 mL 0.1263 mL 0.2526 mL 0.6314 mL
100 mM 0.0202 mL 0.1010 mL 0.2020 mL 0.5051 mL
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PS432 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PS4322083630-26-4PS 432PS-432PKCProtein kinase CInhibitorinhibitorinhibit

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