2. GPCR/G Protein
  3. Adenosine Receptor
  4. PSB-0788

PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases.

For research use only. We do not sell to patients.

PSB-0788 Chemical Structure

PSB-0788 Chemical Structure

CAS No. : 1027513-54-7

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10 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

PSB-0788 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases[1].

IC50 & Target

IC50: 3.64 nM (A2BAdoR)[1].
Ki: 0.393 nM (human, A2B); >1000 nM (A3 human recombinant); 333 nM (A2A human recombinant); 1730 nM (A2A rat brain striatal membranes); 2240 nM (A1 human recombinant); 386 nM (A1 rat brain cortical membranes))[1].
In Vitro

PSB-0788 (compound 17) has high potency at the A2BAdoR with IC50 value of 3.64 nM[1].
PSB-0788 has good profile of affinity and selectivity (Ki: 0.393 nM (A2B human recombinant); >1000 nM (A3 human recombinant); 333 nM (A2A human recombinant); 1730 nM (A2A rat brain striatal membranes); 2240 nM (A1 human recombinant); 386 nM (A1 rat brain cortical membranes))[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PSB-0788 Related Antibodies
Molecular Weight

543.04

Formula

C25H27ClN6O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C(N1CCC)=O)NC(C3=CC=C(S(=O)(N4CCN(CC4)CC5=CC=C(C=C5)Cl)=O)C=C3)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (230.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8415 mL 9.2074 mL 18.4149 mL
5 mM 0.3683 mL 1.8415 mL 3.6830 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8415 mL 9.2074 mL 18.4149 mL 46.0371 mL
5 mM 0.3683 mL 1.8415 mL 3.6830 mL 9.2074 mL
10 mM 0.1841 mL 0.9207 mL 1.8415 mL 4.6037 mL
15 mM 0.1228 mL 0.6138 mL 1.2277 mL 3.0691 mL
20 mM 0.0921 mL 0.4604 mL 0.9207 mL 2.3019 mL
25 mM 0.0737 mL 0.3683 mL 0.7366 mL 1.8415 mL
30 mM 0.0614 mL 0.3069 mL 0.6138 mL 1.5346 mL
40 mM 0.0460 mL 0.2302 mL 0.4604 mL 1.1509 mL
50 mM 0.0368 mL 0.1841 mL 0.3683 mL 0.9207 mL
60 mM 0.0307 mL 0.1535 mL 0.3069 mL 0.7673 mL
80 mM 0.0230 mL 0.1151 mL 0.2302 mL 0.5755 mL
100 mM 0.0184 mL 0.0921 mL 0.1841 mL 0.4604 mL
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PSB-0788 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-07881027513-54-7PSB0788PSB 0788Adenosine ReceptorP1 receptorxanthine-8-yl-benzenesulfonamide derivativeA2Binflammatorylung diseasesInhibitorinhibitorinhibit

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