PSB-1115

Cat. No.: HY-103182 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh).

For research use only. We do not sell to patients.

PSB-1115 Chemical Structure

CAS No. : 152529-79-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of PSB-1115:

PSB-1115 potassium salt Get quote

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View All Adenosine Receptor Isoform Specific Products:

View All Isoforms

Adenosine A₁ receptor (A₁R) Adenosine A_2A receptor (A_2AR) Adenosine A_2B receptor (A_2BR) Adenosine A₃ receptor (A₃R)

Biological Activity
Purity & Documentation
References
Customer Review

Description

PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)^[1].

IC₅₀ & Target^[1]

A2BR

In Vitro

PSB-1115 (100 μM) inhibits TNBS (10 mM) induced ACh contraction inhibition in the ileum/jejunum segment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PSB-1115 (0.5 mg/kg; i.p.; single dose, injected 20 minutes before inhalation) antagonizes the inhibitory effect of the non-selective adenosine receptor agonist NECA (HY-103173) on mucociliary clearance in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

350.35

Formula

C₁₄H₁₄N₄O₅S

CAS No.

152529-79-8

Appearance

Solid

Color

Off-white to light brown

SMILES

O=S(C1=CC=C(C2=NC3=C(NC(N(CCC)C3=O)=O)N2)C=C1)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (285.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 10 mg/mL (28.54 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8543 mL	14.2714 mL	28.5429 mL
5 mM	0.5709 mL	2.8543 mL	5.7086 mL
10 mM	0.2854 mL	1.4271 mL	2.8543 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (245 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)

References

[1]. Michael S, et al. Adenosine A(2A) agonist and A(2B) antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation. Purinergic Signal. 2010 Mar;6(1):117-24. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.8543 mL	14.2714 mL	28.5429 mL	71.3572 mL
	5 mM	0.5709 mL	2.8543 mL	5.7086 mL	14.2714 mL
	10 mM	0.2854 mL	1.4271 mL	2.8543 mL	7.1357 mL
	15 mM	0.1903 mL	0.9514 mL	1.9029 mL	4.7571 mL
	20 mM	0.1427 mL	0.7136 mL	1.4271 mL	3.5679 mL
	25 mM	0.1142 mL	0.5709 mL	1.1417 mL	2.8543 mL
DMSO	30 mM	0.0951 mL	0.4757 mL	0.9514 mL	2.3786 mL
	40 mM	0.0714 mL	0.3568 mL	0.7136 mL	1.7839 mL
	50 mM	0.0571 mL	0.2854 mL	0.5709 mL	1.4271 mL
	60 mM	0.0476 mL	0.2379 mL	0.4757 mL	1.1893 mL
	80 mM	0.0357 mL	0.1784 mL	0.3568 mL	0.8920 mL
	100 mM	0.0285 mL	0.1427 mL	0.2854 mL	0.7136 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

PSB-1115 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-1115152529-79-8PSB1115PSB 1115Adenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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