2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. PSMα3

PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PSMα3 Chemical Structure

PSMα3 Chemical Structure

CAS No. : 1001405-52-2

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5 mg USD 255 In-stock
10 mg USD 340 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of PSMα3:

PSMα3 Related Antibodies

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Description

PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA)[1][2].

Molecular Weight

2635.13

Formula

C128H192N28O30S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{f}-Met-Glu-Phe-Val-Ala-Lys-Leu-Phe-Lys-Phe-Phe-Lys-Asp-Leu-Leu-Gly-Lys-Phe-Leu-Gly-Asn-Asn
Sequence Shortening

{f}-MEFVAKLFKFFKDLLGKFLGNN
Structure Classification
Initial Source

S. aureus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (37.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3795 mL 1.8974 mL 3.7949 mL
5 mM 0.0759 mL 0.3795 mL 0.7590 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3795 mL 1.8974 mL 3.7949 mL 9.4872 mL
5 mM 0.0759 mL 0.3795 mL 0.7590 mL 1.8974 mL
10 mM 0.0379 mL 0.1897 mL 0.3795 mL 0.9487 mL
15 mM 0.0253 mL 0.1265 mL 0.2530 mL 0.6325 mL
20 mM 0.0190 mL 0.0949 mL 0.1897 mL 0.4744 mL
25 mM 0.0152 mL 0.0759 mL 0.1518 mL 0.3795 mL
30 mM 0.0126 mL 0.0632 mL 0.1265 mL 0.3162 mL
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PSMα3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMα31001405-52-2PSMα 3PSMα-3Toll-like Receptor (TLR)peptideDCstolerogenicvaccinationTLR2TLR4pro-inflammatoryanti-inflammatorycytokineMRSAInhibitorinhibitorinhibit

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