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PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine.

For research use only. We do not sell to patients.

PU 23 Chemical Structure

PU 23 Chemical Structure

CAS No. : 817635-93-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 110 In-stock
Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 160 In-stock
25 mg USD 335 In-stock
50 mg USD 530 In-stock
100 mg USD 840 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

PU 23 Related Antibodies

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Description

PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine[1].

In Vitro

6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 2.81 and 14.11 μM, respectively. The combination of PU 23 (Cpd23) and 6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 1.84 and 6.06 μM, respectively[1].
Preincubation of HEK293/MRP4 cells with PU 23 (50 μM) for 2 h also significantly increases the amount of 6-MP in cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PU 23 Related Antibodies
Molecular Weight

425.52

Formula

C21H19N3O3S2
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(NC(NC1=CC=C(S(=O)(NCC2=CC=CC=C2)=O)C=C1)=S)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (293.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3501 mL 11.7503 mL 23.5007 mL
5 mM 0.4700 mL 2.3501 mL 4.7001 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3501 mL 11.7503 mL 23.5007 mL 58.7516 mL
5 mM 0.4700 mL 2.3501 mL 4.7001 mL 11.7503 mL
10 mM 0.2350 mL 1.1750 mL 2.3501 mL 5.8752 mL
15 mM 0.1567 mL 0.7834 mL 1.5667 mL 3.9168 mL
20 mM 0.1175 mL 0.5875 mL 1.1750 mL 2.9376 mL
25 mM 0.0940 mL 0.4700 mL 0.9400 mL 2.3501 mL
30 mM 0.0783 mL 0.3917 mL 0.7834 mL 1.9584 mL
40 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
50 mM 0.0470 mL 0.2350 mL 0.4700 mL 1.1750 mL
60 mM 0.0392 mL 0.1958 mL 0.3917 mL 0.9792 mL
80 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
100 mM 0.0235 mL 0.1175 mL 0.2350 mL 0.5875 mL
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PU 23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PU 23817635-93-1PU23PU-23OthersmultidrugresistanceproteinMRP46-MercaptopurineInhibitorinhibitorinhibit

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