PXS-4787 hydrochloride

Cat. No.: HY-151498A: FAQs
Data Sheet Handling Instructions

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PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 hydrochloride inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively. PXS-4787 hydrochloride reduces deposition and crosslinking of collagen I secreted by human fibroblasts.

For research use only. We do not sell to patients.

PXS-4787 hydrochloride Chemical Structure

CAS No. : 2409964-40-3

Size	Price	Stock	Quantity
5 mg	USD 375	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1176	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1823	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2735	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PXS-4787 hydrochloride:

PXS-4787 Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4)^[1]

Molecular Weight

265.73

Formula

C₁₀H₁₃ClFNO₂S

CAS No.

2409964-40-3

SMILES

NC/C=C(CS(=O)(C1=CC=CC=C1)=O)\F.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (376.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7632 mL	18.8161 mL	37.6322 mL
5 mM	0.7526 mL	3.7632 mL	7.5264 mL
10 mM	0.3763 mL	1.8816 mL	3.7632 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7632 mL	18.8161 mL	37.6322 mL	94.0805 mL
	5 mM	0.7526 mL	3.7632 mL	7.5264 mL	18.8161 mL
	10 mM	0.3763 mL	1.8816 mL	3.7632 mL	9.4080 mL
	15 mM	0.2509 mL	1.2544 mL	2.5088 mL	6.2720 mL
	20 mM	0.1882 mL	0.9408 mL	1.8816 mL	4.7040 mL
	25 mM	0.1505 mL	0.7526 mL	1.5053 mL	3.7632 mL
	30 mM	0.1254 mL	0.6272 mL	1.2544 mL	3.1360 mL
	40 mM	0.0941 mL	0.4704 mL	0.9408 mL	2.3520 mL
	50 mM	0.0753 mL	0.3763 mL	0.7526 mL	1.8816 mL
	60 mM	0.0627 mL	0.3136 mL	0.6272 mL	1.5680 mL
	80 mM	0.0470 mL	0.2352 mL	0.4704 mL	1.1760 mL
	100 mM	0.0376 mL	0.1882 mL	0.3763 mL	0.9408 mL