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  3. Isotope-Labeled Compounds
  4. Pyridinium bisretinoid A2E-d4 TFA

Pyridinium bisretinoid A2E-d4 TFA  (Synonyms: A2E-d4 TFA)

Cat. No.: HY-134928AS Purity: ≥90.0%
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Pyridinium bisretinoid A2E-d4 TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species.

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Pyridinium bisretinoid A2E-d<sub>4</sub> TFA Chemical Structure

Pyridinium bisretinoid A2E-d4 TFA Chemical Structure

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1 mg USD 1300 In-stock
5 mg USD 3250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pyridinium bisretinoid A2E-d4 TFA:

Pyridinium bisretinoid A2E-d4 TFA Related Antibodies

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Description

Pyridinium bisretinoid A2E-d4 TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyridinium bisretinoid A2E-d4 TFA Related Antibodies
Molecular Weight

709.96

Formula

C44H54D4F3NO3
Unlabeled CAS

1821308-73-9
Appearance

Solid

Color

Brown to reddish brown

SMILES

OC([2H])([2H])C([2H])([2H])[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C.O=C([O-])C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (5.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4085 mL 7.0426 mL 14.0853 mL
5 mM 0.2817 mL 1.4085 mL 2.8171 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4085 mL 7.0427 mL 14.0853 mL 35.2133 mL
5 mM 0.2817 mL 1.4085 mL 2.8171 mL 7.0427 mL
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Pyridinium bisretinoid A2E-d4 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridinium bisretinoid A2E-d4A2E-d4Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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