2. Apoptosis Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Autophagy Reactive Oxygen Species
  4. Pyridinium bisretinoid A2E

Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases.

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Pyridinium bisretinoid A2E Chemical Structure

Pyridinium bisretinoid A2E Chemical Structure

CAS No. : 173449-96-2

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Other Forms of Pyridinium bisretinoid A2E:

Pyridinium bisretinoid A2E Related Antibodies

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Description

Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases[1][2].

In Vitro

Exposure of Pyridinium bisretinoid A2E (A2E) to light triggers its conversion into at least two products. One of these is epoxy-A2E, which is hydrophilic and can be transferred from the membrane to an aqueous solution. The other product is an unidentified hydrophobic substance[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyridinium bisretinoid A2E Related Antibodies
Molecular Weight

592.92

Formula

C42H58NO+
CAS No.
SMILES

OCC[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (252.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6866 mL 8.4328 mL 16.8657 mL
5 mM 0.3373 mL 1.6866 mL 3.3731 mL
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6866 mL 8.4328 mL 16.8657 mL 42.1642 mL
5 mM 0.3373 mL 1.6866 mL 3.3731 mL 8.4328 mL
10 mM 0.1687 mL 0.8433 mL 1.6866 mL 4.2164 mL
15 mM 0.1124 mL 0.5622 mL 1.1244 mL 2.8109 mL
20 mM 0.0843 mL 0.4216 mL 0.8433 mL 2.1082 mL
25 mM 0.0675 mL 0.3373 mL 0.6746 mL 1.6866 mL
30 mM 0.0562 mL 0.2811 mL 0.5622 mL 1.4055 mL
40 mM 0.0422 mL 0.2108 mL 0.4216 mL 1.0541 mL
50 mM 0.0337 mL 0.1687 mL 0.3373 mL 0.8433 mL
60 mM 0.0281 mL 0.1405 mL 0.2811 mL 0.7027 mL
80 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.5271 mL
100 mM 0.0169 mL 0.0843 mL 0.1687 mL 0.4216 mL
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Pyridinium bisretinoid A2E Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridinium bisretinoid A2E173449-96-2A2EApoptosisAutophagyReactive Oxygen SpeciesROSblue-lightPhotoactivationInhibitorinhibitorinhibit

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