2. Cell Cycle/DNA Damage
  3. G-quadruplex
  4. Pyridostatin TFA

Pyridostatin TFA  (Synonyms: RR82 TFA)

Cat. No.: HY-15176B Purity: 99.54%
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Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin TFA promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin TFA targets the proto-oncogene Src. Pyridostatin TFA reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.

For research use only. We do not sell to patients.

Pyridostatin TFA Chemical Structure

Pyridostatin TFA Chemical Structure

CAS No. : 1472611-44-1

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5 mg USD 93 In-stock
10 mg USD 140 In-stock
25 mg USD 280 In-stock
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Based on 20 publication(s) in Google Scholar

Other Forms of Pyridostatin TFA:

Pyridostatin TFA Related Antibodies

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Description

Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin TFA promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin TFA targets the proto-oncogene Src. Pyridostatin TFA reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells[1][2][3].

In Vitro

Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest[1].
Pyridostatin TFA is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin TFA causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin TFA induces the formation of DNA DSBs. Remarkably, Pyridostatin TFA (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyridostatin TFA Related Antibodies

Cell Viability Assay[1]

Cell Line: Over 60 different cancer cell lines
Concentration: 10 μM
Incubation Time: 48 hours
Result: Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines.
Molecular Weight

710.66

Formula

C33H33F3N8O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NC(C(NC2=NC3=CC=CC=C3C(OCCN)=C2)=O)=CC(OCCN)=C1)NC4=NC5=CC=CC=C5C(OCCN)=C4.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (140.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4071 mL 7.0357 mL 14.0714 mL
5 mM 0.2814 mL 1.4071 mL 2.8143 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4071 mL 7.0357 mL 14.0714 mL 35.1786 mL
5 mM 0.2814 mL 1.4071 mL 2.8143 mL 7.0357 mL
10 mM 0.1407 mL 0.7036 mL 1.4071 mL 3.5179 mL
15 mM 0.0938 mL 0.4690 mL 0.9381 mL 2.3452 mL
20 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.7589 mL
25 mM 0.0563 mL 0.2814 mL 0.5629 mL 1.4071 mL
30 mM 0.0469 mL 0.2345 mL 0.4690 mL 1.1726 mL
40 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8795 mL
50 mM 0.0281 mL 0.1407 mL 0.2814 mL 0.7036 mL
60 mM 0.0235 mL 0.1173 mL 0.2345 mL 0.5863 mL
80 mM 0.0176 mL 0.0879 mL 0.1759 mL 0.4397 mL
100 mM 0.0141 mL 0.0704 mL 0.1407 mL 0.3518 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pyridostatin TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridostatin1472611-44-1RR82RR 82RR-82G-quadruplexstructureDNAdamageneurodegenerationDSBcyclearrestSRCInhibitorinhibitorinhibit

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