Pyridoxal Phosphate-d₃ (Synonyms: Pyridoxal 5'-phosphate-d₃)

Cat. No.: HY-W011727S Purity: 98.01%: FAQs
Data Sheet SDS COA Handling Instructions

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Pyridoxal Phosphate-d₃ is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate hydrate is an endogenous metabolite.

For research use only. We do not sell to patients.

Pyridoxal Phosphate-d<sub>3</sub> Chemical Structure

Pyridoxal Phosphate-d₃ Chemical Structure

CAS No. : 1354560-58-9

Size	Price	Stock	Quantity
1 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Other Forms of Pyridoxal Phosphate-d₃:

Pyridoxal 5'-phosphate hydrate Get quote

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Description

Pyridoxal Phosphate-d₃ is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate hydrate is an endogenous metabolite.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

250.16

Formula

C₈H₇D₃NO₆P

CAS No.

1354560-58-9

Unlabeled CAS

853645-22-4

Appearance

Solid

Color

White to off-white

SMILES

O=CC1=C(O)C(C([2H])([2H])[2H])=NC=C1COP(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (249.84 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9974 mL	19.9872 mL	39.9744 mL
5 mM	0.7995 mL	3.9974 mL	7.9949 mL
10 mM	0.3997 mL	1.9987 mL	3.9974 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.01%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (251 KB) HNMR (110 KB) RP-HPLC (178 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9974 mL	19.9872 mL	39.9744 mL	99.9360 mL
	5 mM	0.7995 mL	3.9974 mL	7.9949 mL	19.9872 mL
	10 mM	0.3997 mL	1.9987 mL	3.9974 mL	9.9936 mL
	15 mM	0.2665 mL	1.3325 mL	2.6650 mL	6.6624 mL
	20 mM	0.1999 mL	0.9994 mL	1.9987 mL	4.9968 mL
	25 mM	0.1599 mL	0.7995 mL	1.5990 mL	3.9974 mL
	30 mM	0.1332 mL	0.6662 mL	1.3325 mL	3.3312 mL
	40 mM	0.0999 mL	0.4997 mL	0.9994 mL	2.4984 mL
	50 mM	0.0799 mL	0.3997 mL	0.7995 mL	1.9987 mL
	60 mM	0.0666 mL	0.3331 mL	0.6662 mL	1.6656 mL
	80 mM	0.0500 mL	0.2498 mL	0.4997 mL	1.2492 mL
	100 mM	0.0400 mL	0.1999 mL	0.3997 mL	0.9994 mL

Pyridoxal Phosphate-d₃ Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridoxal Phosphate-d₃1354560-58-9Pyridoxal 5'-phosphate-d₃Endogenous MetaboliteInhibitorinhibitorinhibit

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Pyridoxal Phosphate-d3 (Synonyms: Pyridoxal 5'-phosphate-d3)

Other Forms of Pyridoxal Phosphate-d3:

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Complete Stock Solution Preparation Table

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