2. Metabolic Enzyme/Protease Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway
  3. Endogenous Metabolite Amyloid-β ERK
  4. Pyridoxal 5'-phosphate hydrate

Pyridoxal 5'-phosphate hydrate  (Synonyms: Pyridoxal phosphate hydrate)

Cat. No.: HY-W011727 Purity: 99.76%
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Handling Instructions Technical Support

Pyridoxal 5'-phosphate hydrate is an endogenous metabolite.

For research use only. We do not sell to patients.

Pyridoxal 5'-phosphate hydrate Chemical Structure

Pyridoxal 5'-phosphate hydrate Chemical Structure

CAS No. : 853645-22-4

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1 g In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pyridoxal 5'-phosphate hydrate:

Pyridoxal 5'-phosphate hydrate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pyridoxal 5'-phosphate hydrate

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ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pyridoxal 5'-phosphate hydrate is an endogenous metabolite.

In Vitro

Pyridoxal 5'-phosphate hydrate (500 μM, 24 h) activates the ERK/c-Jun signaling pathway, promotes the expression of IGFBP1 protein in HepG2 cells[3].
Pyridoxal 5'-phosphate hydrate (0.5 mg/mL, 48h) inhibits the proliferation of cancer cells SK-OV-3 and OVCAR-3[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyridoxal 5'-phosphate hydrate Related Antibodies

Western Blot Analysis[3]

Cell Line: HepG2
Concentration: 500 μM
Incubation Time: 24 h
Result: Promoted the phosphorylation of ERK1 and c-Jun protein.

Western Blot Analysis[5]

Cell Line: SK-OV-3 and OVCAR-3
Concentration: 0.5 mg/mL
Incubation Time: 48 h
Result: Inhibited the proliferation.
In Vivo

Pyridoxal 5'-phosphate hydrate (1 mg/kg, ip, single dose) alleviates Aβ25-35-induced spatial memory impairment and long-term memory impairment in mouse models[4].
Pyridoxal 5'-phosphate hydrate (600 mg/kg/day, po for 16 weeks) inhibits the formation of advanced glycation end-products (AGEs), and prevents the progression of diabetic nephropathy in Streptozotocin (HY-13753)-induced rats diabetes model[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Aβ25-35-induced cognitive dysfunction in ICR mouse models[4]
Dosage: 1 mg/kg
Administration: ip, single dose
Result: Alleviated spatial and long-term memory impairment.
Animal Model: Streptozotocin (HY-13753)-induced rats diabetes model[6]
Dosage: 600 mg/kg
Administration: po for 16 weeks
Result: Prevented the diabetes.
Molecular Weight

247.14

Formula

C8H10NO6P
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=CC1=C(O)C(C)=NC=C1COP(O)(O)=O.[x H2O]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 2.5 mg/mL (10.12 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0463 mL 20.2314 mL 40.4629 mL
5 mM 0.8093 mL 4.0463 mL 8.0926 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0463 mL 20.2314 mL 40.4629 mL 101.1572 mL
5 mM 0.8093 mL 4.0463 mL 8.0926 mL 20.2314 mL
10 mM 0.4046 mL 2.0231 mL 4.0463 mL 10.1157 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pyridoxal 5'-phosphate hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridoxal 5'-phosphate853645-22-4Pyridoxal phosphateEndogenous MetaboliteAmyloid-βERKβ-amyloid peptideAβAbetaExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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