2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Pyrrophenone

Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM.

For research use only. We do not sell to patients.

Pyrrophenone Chemical Structure

Pyrrophenone Chemical Structure

CAS No. : 341973-06-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Based on 4 publication(s) in Google Scholar

Pyrrophenone Related Antibodies

Top Publications Citing Use of Products

    Pyrrophenone purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023, 24(2), 1375.

    In HeLa cells transfected with AFP, pyrrophenone inhibits the delivery of AFP at the trans-side of the GC (Figure M-O).

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM[1].

    IC50 & Target[1]

    cPLA2α

    4.2 nM (IC50)

    In Vitro

    Pyrrophenone shows potent inhibition of arachidonic acid release, prostaglandin E2, thromboxane B2, and leukotriene B4 formation in human whole blood[1].
    Pyrrophenone inhibits the production of arachidonic acid (AA) (IC50=24±1.7 nM), PGE2 (IC50=25±19 nM),, and LTC4 (IC50=14±6.7 nM),from THP-1 cells stimulated with A23187[1].
    Pyrrophenone inhibits the production of AA (IC50=0.19±0.068 μM), PGE2 (IC50=0.20±0.047 μM), TXB2 (IC50=0.16±0.093 μM),and LTB4 (IC50=0.32±0.24 μM) from human whole blood stimulated with A23187[1].
    Pyrrophenone (0.1-0.5 μM, 48 h) inhibits the growth of PC-PTC3 and PCCl3 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Pyrrophenone Related Antibodies

    Cell Proliferation Assay[2]

    Cell Line: PC-PTC3 and PCCl3 cells
    Concentration: 0.1, 0.3, and 0.5 μM
    Incubation Time: 48 hours
    Result: Significantly inhibited basal PC-PTC3 cell proliferation at concentrations as low as 0.1 μM.
    Basal cell proliferation of normal PCCl3 cells was also inhibited by 0.5 μM, although to a lesser extent.
    In Vivo

    Pyrrophenone (administered i.p. at 20 mg/kg 30 min before LPS injection.) suppresses bronchoalveolar lavage (BAL) levels of leukotriene B4 (LTB4) and platelet activating factor (PAF)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Specific pathogen-free female BALB/c mice[3]
    Dosage: 20 mg/kg
    Administration: Administered i.p. 30 min before LPS injection
    Result: Suppressed the recruitment of neutrophils and eosinophils, but not macrophages.
    Molecular Weight

    849.96

    Formula

    C49H37F2N3O5S2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(NC[C@H]1N(C(C2=CC=CC=C2C(C3=CC=C(F)C=C3F)=O)=O)C[C@H](SC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C1)C7=CC=C(/C=C(SC(N8)=O)/C8=O)C=C7
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (117.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1765 mL 5.8826 mL 11.7653 mL
    5 mM 0.2353 mL 1.1765 mL 2.3531 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.1765 mL 5.8826 mL 11.7653 mL 29.4131 mL
    5 mM 0.2353 mL 1.1765 mL 2.3531 mL 5.8826 mL
    10 mM 0.1177 mL 0.5883 mL 1.1765 mL 2.9413 mL
    15 mM 0.0784 mL 0.3922 mL 0.7844 mL 1.9609 mL
    20 mM 0.0588 mL 0.2941 mL 0.5883 mL 1.4707 mL
    25 mM 0.0471 mL 0.2353 mL 0.4706 mL 1.1765 mL
    30 mM 0.0392 mL 0.1961 mL 0.3922 mL 0.9804 mL
    40 mM 0.0294 mL 0.1471 mL 0.2941 mL 0.7353 mL
    50 mM 0.0235 mL 0.1177 mL 0.2353 mL 0.5883 mL
    60 mM 0.0196 mL 0.0980 mL 0.1961 mL 0.4902 mL
    80 mM 0.0147 mL 0.0735 mL 0.1471 mL 0.3677 mL
    100 mM 0.0118 mL 0.0588 mL 0.1177 mL 0.2941 mL
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    Pyrrophenone Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pyrrophenone341973-06-6PhospholipaseCytosolicA2αPLA2IVαInhibitorinhibitorinhibit

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