QN523

Name: QN523
Brand: MedChemExpress
SKU: HY-148255
Rating: 4.5 (1 reviews)

Cat. No.: HY-148255 Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

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QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer.

For research use only. We do not sell to patients.

QN523 Chemical Structure

CAS No. : 878581-60-3

Size	Price	Stock	Quantity
5 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 440	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
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Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	3.3 μM Compound: QN523; 2	Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HCT-116	IC₅₀	0.1 μM Compound: QN523; 2	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HEK293	IC₅₀	0.15 μM Compound: QN523; 2	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
Hep 3B2	IC₅₀	0.21 μM Compound: QN523; 2	Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HepG2	IC₅₀	0.5 μM Compound: QN523; 2	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HFF-1	IC₅₀	> 30 μM Compound: QN523; 2	Cytotoxicity against human HFF-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HFF-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
Jurkat	IC₅₀	0.1 μM Compound: QN523; 2	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
MIA PaCa-2	IC₅₀	0.11 μM Compound: QN523; 2	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
OVCAR-8	IC₅₀	0.3 μM Compound: QN523; 2	Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
PANC-1	IC₅₀	0.5 μM Compound: QN523; 2	Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
SNU-387	IC₅₀	5.73 μM Compound: QN523; 2	Antiproliferative activity against human SNU-387 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SNU-387 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
SNU-398	IC₅₀	1.9 μM Compound: QN523; 2	Antiproliferative activity against human SNU-398 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SNU-398 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
SNU-449	IC₅₀	0.4 μM Compound: QN523; 2	Antiproliferative activity against human SNU-449 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SNU-449 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
SNU-475	IC₅₀	2.67 μM Compound: QN523; 2	Antiproliferative activity against human SNU-475 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SNU-475 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]

In Vitro

QN523 (72 h) has cytotoxicity with IC₅₀ values ranging from 0.1 to 5.7 μM across 12 cell lines^[1].
QN523 (0.1 and 0.5 μM; 24 and 48 h; MIA PaCa-2 cells) arrests cell cycle at S phase and delays for pancreatic cancer cells to enter the G2-M phase. QN523 induces apoptosis and autophagy of MIA PaCa-2 Cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	MIA PaCa-2 cells
Concentration:	0.1 and 0.5 μM
Incubation Time:	24 and 48 hours
Result:	Delayed for pancreatic cancer cells to enter the G2-M phase because of accumulation of cells in the S phase.

Apoptosis Analysis^[1]

Cell Line:	MIA PaCa-2 cells
Concentration:	0.1 and 0.5 μM
Incubation Time:	24 and 48 hours
Result:	Increased the number of apoptotic cell in time- and dose-dependent manner.

In Vivo

QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age)
Dosage:	10 and 20 mg/kg
Administration:	Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg)
Result:	Delayed growth of the tumors, and no systemic toxicity.

Molecular Weight

250.26

Formula

C₁₄H₁₀N₄O

CAS No.

878581-60-3

Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C1=NC=CN=C1)NC2=CC=CC3=CC=CN=C32

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 16.67 mg/mL (66.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9958 mL	19.9792 mL	39.9584 mL
5 mM	0.7992 mL	3.9958 mL	7.9917 mL
10 mM	0.3996 mL	1.9979 mL	3.9958 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (252 KB) HNMR (235 KB) LCMS (268 KB)

Handling Instructions (2659 KB)

References

[1]. Kuang Y, et, al. Induction of Genes Implicated in Stress Response and Autophagy by a Novel Quinolin-8-yl-nicotinamide QN523 in Pancreatic Cancer. J Med Chem. 2022 Apr 28;65(8):6133-6156. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9958 mL	19.9792 mL	39.9584 mL	99.8961 mL
	5 mM	0.7992 mL	3.9958 mL	7.9917 mL	19.9792 mL
	10 mM	0.3996 mL	1.9979 mL	3.9958 mL	9.9896 mL
	15 mM	0.2664 mL	1.3319 mL	2.6639 mL	6.6597 mL
	20 mM	0.1998 mL	0.9990 mL	1.9979 mL	4.9948 mL
	25 mM	0.1598 mL	0.7992 mL	1.5983 mL	3.9958 mL
	30 mM	0.1332 mL	0.6660 mL	1.3319 mL	3.3299 mL
	40 mM	0.0999 mL	0.4995 mL	0.9990 mL	2.4974 mL
	50 mM	0.0799 mL	0.3996 mL	0.7992 mL	1.9979 mL
	60 mM	0.0666 mL	0.3330 mL	0.6660 mL	1.6649 mL

QN523 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QN523878581-60-3QN 523QN-523ApoptosisAutophagyanticancerdrug-like propertycytotoxicitycancer cellInhibitorinhibitorinhibit

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QN523

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