2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. QO 58

QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability.

For research use only. We do not sell to patients.

QO 58 Chemical Structure

QO 58 Chemical Structure

CAS No. : 1259536-62-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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 USD 132 In-stock
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10 mM * 1 mL in DMSO USD 132 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

QO 58 Related Antibodies

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  • Purity & Documentation

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Description

QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
0.06 μM
Compound: 17
Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay
Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay
[PMID: 21296466]
HEK293 EC50
49.29 μM
Compound: 17
Activation of KCNQ1 expressed in HEK293 cells by atomic absorption Rb'+ efflux assay
Activation of KCNQ1 expressed in HEK293 cells by atomic absorption Rb'+ efflux assay
[PMID: 21296466]
Molecular Weight

443.18

Formula

C18H8Cl2F4N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(C2=C(Cl)N=C(Cl)C(F)=C2)NC3=C(C(C(F)(F)F)=NN13)C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 62.5 mg/mL (141.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2564 mL 11.2821 mL 22.5642 mL
5 mM 0.4513 mL 2.2564 mL 4.5128 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2564 mL 11.2821 mL 22.5642 mL 56.4105 mL
5 mM 0.4513 mL 2.2564 mL 4.5128 mL 11.2821 mL
10 mM 0.2256 mL 1.1282 mL 2.2564 mL 5.6410 mL
15 mM 0.1504 mL 0.7521 mL 1.5043 mL 3.7607 mL
20 mM 0.1128 mL 0.5641 mL 1.1282 mL 2.8205 mL
25 mM 0.0903 mL 0.4513 mL 0.9026 mL 2.2564 mL
30 mM 0.0752 mL 0.3761 mL 0.7521 mL 1.8803 mL
40 mM 0.0564 mL 0.2821 mL 0.5641 mL 1.4103 mL
50 mM 0.0451 mL 0.2256 mL 0.4513 mL 1.1282 mL
60 mM 0.0376 mL 0.1880 mL 0.3761 mL 0.9402 mL
80 mM 0.0282 mL 0.1410 mL 0.2821 mL 0.7051 mL
100 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5641 mL
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QO 58 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QO 581259536-62-3QO58QO-58Potassium ChannelKcsAK(v)7 channelscurrent amplitudeneuronal hyperexcitabilityInhibitorinhibitorinhibit

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