2. Anti-infection Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Apoptosis
  3. Parasite Potassium Channel Cytochrome P450 Apoptosis
  4. Quinidine gluconic acid

Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selective cytochrome P450db inhibitor. Quinate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinate can be used for malaria research.

For research use only. We do not sell to patients.

Quinidine gluconic acid Chemical Structure

Quinidine gluconic acid Chemical Structure

CAS No. : 7054-25-3

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Other In-stock Forms of Quinidine gluconic acid:

Other Forms of Quinidine gluconic acid:

Quinidine gluconic acid Related Antibodies

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selective cytochrome P450db inhibitor. Quinate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinate can be used for malaria research[1][2][3][4].

IC50 & Target

Plasmodium

 

In Vitro

Quinate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quinidine gluconic acid Related Antibodies

Cell Cytotoxicity Assay[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

Apoptosis Analysis[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
In Vivo

Quinate shows effects on the PTZ-induced seizure threshold[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
Dosage: 10, 20, and 30 mg/kg
Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
Molecular Weight

520.57

Formula

C26H36N2O9
CAS No.
SMILES

C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Quinidine gluconic acid Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinidine7054-25-3ParasitePotassium ChannelCytochrome P450ApoptosisKcsACYPsoral activitymalariaMES-SAMESSA/DX5Inhibitorinhibitorinhibit

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