2. Metabolic Enzyme/Protease Anti-infection Membrane Transporter/Ion Channel Apoptosis
  3. Cytochrome P450 Parasite Potassium Channel Apoptosis
  4. Quinidine sulfate dihydrate

Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research.

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Quinidine sulfate dihydrate Chemical Structure

Quinidine sulfate dihydrate Chemical Structure

CAS No. : 6591-63-5

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Other Forms of Quinidine sulfate dihydrate:

Quinidine sulfate dihydrate Related Antibodies

Top Publications Citing Use of Products

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research[1][2][3][4].

IC50 & Target

Plasmodium

 

In Vitro

Quinidine sulfate dihydrate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quinidine sulfate dihydrate Related Antibodies

Cell Cytotoxicity Assay[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

Apoptosis Analysis[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
In Vivo

Quinidine sulfate dihydrate shows effects on the PTZ-induced seizure threshold[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
Dosage: 10, 20, and 30 mg/kg
Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
Molecular Weight

405.50

Formula

C21H30N2O7S
CAS No.
SMILES

O=S(O)(O)=O.[H]O[H].C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2(C)[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.[0.5]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Quinidine sulfate dihydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinidine sulfate dihydrate6591-63-5Cytochrome P450ParasitePotassium ChannelApoptosisCYPsKcsAoral activitymalariaMES-SAMESSA/DX5Inhibitorinhibitorinhibit

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