Quinfamide (Synonyms: WIN-40014)

Cat. No.: HY-119826 Purity: 99.69%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Quinfamide (WIN-40014) is an orally active class of dichloroacetyl derivative with significant anti-intestinal protozoan, particularly mmoeba histolytica activity. Quinfamide exhibits antiamoebic activity under solvent-free conditions with an IC₅₀ of 28.15 μg/mL in a suspension condition. Quinfamide particles are actively engulfed by the amoebas, then cells are affected, and finally, amoebas are killed and lysed, and this process directly relies on the physical intake of the drug particles. Quinfamide can be used in the research of tropical parasitic infections such as amoebiasis and helminthiasis.

For research use only. We do not sell to patients.

Quinfamide Chemical Structure

CAS No. : 62265-68-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Parasite Isoform Specific Products:

View All Isoforms

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Amebae

In Vitro

Quinfamide inhibits propagation of E. histolytica in vitro at a concentration of 20 μg/mL^[2].
Quinfamide (0-72 h) granules are actively engulfed by the amoeba, and subsequently the amoeba's trophozoite cells become round, lose their motility, undergo cell lysis, and the integrity of the cell membrane is lost^[3].
Quinfamide has an IC₅₀ value against pathogenic strain of Trichomonas vaginalis (strain GT-13) of 214.7 μg/mL^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Quinfamide (30 mg/kg, p.o., prepared as small pellets and mixed with feed, for 49 days) possesses a low anticoccidial efficacy, this is noticeably improved when prepared as pellets with Carbopol^[1].
Quinfamide (p.o.) exhibits ED₅₀ values against E. cricetid of 0.25 mg/kg/day (total dose 0.75 mg/kg) in multiple doses for 3 days and 0.9 mg/kg after a single dose^[2].
Quinfamide (p.o.) protect hamsters from re-infection with E. cricetid and has no significant toxicity in rodents (10 g/kg, single dose), monkeys (500 mg/kg, for 37 days), dogs (2 g/kg, single dose) and rats (500 mg/kg, for 31 days)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Coccidial infection induced by E. acervuline, E. maxima and E. tenella established in one-day old broiler chickens^[1]
Dosage:	30 mg/kg alone or with 0.1% Carbopol
Administration:	Oral administration (p.o.), prepared as small pellets and mixed with feed, for 49 days
Result:	Increased the weight of the broiler chickens, reduced the amount of egg sacs excreted, and alleviated intestinal lesions but that the combined inhibition was more remarkable.

Clinical Trial

Molecular Weight

354.18

Formula

C₁₆H₁₃Cl₂NO₄

CAS No.

62265-68-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OC1=CC2=C(C=C1)N(CCC2)C(C(Cl)Cl)=O)C3=CC=CO3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL (352.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8234 mL	14.1171 mL	28.2342 mL
5 mM	0.5647 mL	2.8234 mL	5.6468 mL
10 mM	0.2823 mL	1.4117 mL	2.8234 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (251 KB) HNMR (275 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Itzcoatl Aquino, et al. In vivo anticoccidial activity of quinfamide in broilers: a preliminary report. 2016 Mar

[2]. Slighter RG, et al. Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis. Parasitology. 1980 Aug;81(1):157-68. [Content Brief]

[3]. Anaya-Velázquez F, Morales-Fuentes L. Phagocytosis of quinfamide particles by Entamoeba histolytica. Arch Med Res. 2000 Jul-Aug;31(4 Suppl):S10-1. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8234 mL	14.1171 mL	28.2342 mL	70.5856 mL
	5 mM	0.5647 mL	2.8234 mL	5.6468 mL	14.1171 mL
	10 mM	0.2823 mL	1.4117 mL	2.8234 mL	7.0586 mL
	15 mM	0.1882 mL	0.9411 mL	1.8823 mL	4.7057 mL
	20 mM	0.1412 mL	0.7059 mL	1.4117 mL	3.5293 mL
	25 mM	0.1129 mL	0.5647 mL	1.1294 mL	2.8234 mL
	30 mM	0.0941 mL	0.4706 mL	0.9411 mL	2.3529 mL
	40 mM	0.0706 mL	0.3529 mL	0.7059 mL	1.7646 mL
	50 mM	0.0565 mL	0.2823 mL	0.5647 mL	1.4117 mL
	60 mM	0.0471 mL	0.2353 mL	0.4706 mL	1.1764 mL
	80 mM	0.0353 mL	0.1765 mL	0.3529 mL	0.8823 mL
	100 mM	0.0282 mL	0.1412 mL	0.2823 mL	0.7059 mL

Quinfamide Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinfamide62265-68-3WIN-40014WIN40014WIN 40014ParasiteAnticoccidialBroilersCoccidiosisPelletsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *