2. Protein Tyrosine Kinase/RTK PROTAC Apoptosis Autophagy
  3. FLT3 Ligands for Target Protein for PROTAC Apoptosis Autophagy
  4. Quizartinib (Standard)

Quizartinib (Standard) 

Cat. No.: HY-13001R Purity: ≥98%
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Quizartinib (Standard) is the analytical standard of Quizartinib. This product is intended for research and analytical applications. Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis.

For research use only. We do not sell to patients.

Quizartinib (Standard) Chemical Structure

Quizartinib (Standard) Chemical Structure

CAS No. : 950769-58-1

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Description
Molecular Weight

560.67

Formula

C29H32N6O4S
CAS No.
SMILES

O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Quizartinib (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quizartinib (Standard)950769-58-1FLT3Ligands for Target Protein for PROTACApoptosisAutophagyCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Target Protein-binding MoietyoralselectiveAMLacutemyeloidleukemiaFLT3-ITDmutationInhibitorinhibitorinhibit

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