2. Immunology/Inflammation
  3. Interleukin Related
  4. (R)-IL-17 modulator 4

(R)-IL-17 modulator 4 

Cat. No.: HY-141692B Purity: 99.57% ee.: 96.58%
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(R)-IL-17 modulator 4 is the R-configure of IL-17 modulator 4 (HY-141692). IL-17 modulator 4 is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator.

For research use only. We do not sell to patients.

(R)-IL-17 modulator 4 Chemical Structure

(R)-IL-17 modulator 4 Chemical Structure

CAS No. : 2446804-29-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 856 In-stock
Solution
10 mM * 1 mL in DMSO USD 856 In-stock
Solid
1 mg USD 280 In-stock
5 mg USD 820 In-stock
10 mg USD 1320 In-stock
25 mg USD 2650 In-stock
50 mg USD 4250 In-stock
100 mg USD 6800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-IL-17 modulator 4:

(R)-IL-17 modulator 4 Related Antibodies

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View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

(R)-IL-17 modulator 4 is the R-configure of IL-17 modulator 4 (HY-141692). IL-17 modulator 4 is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator[1].

IC50 & Target

IL-17

 

Molecular Weight

474.60

Formula

C27H34N6O2
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C(C1=CC=NN1C(C)C)N[C@@H](C(NC2=CC=C(C3=C(C)NN=C3C)C=C2)=O)C(C4CC4)C5CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (210.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1070 mL 10.5352 mL 21.0704 mL
5 mM 0.4214 mL 2.1070 mL 4.2141 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1070 mL 10.5352 mL 21.0704 mL 52.6759 mL
5 mM 0.4214 mL 2.1070 mL 4.2141 mL 10.5352 mL
10 mM 0.2107 mL 1.0535 mL 2.1070 mL 5.2676 mL
15 mM 0.1405 mL 0.7023 mL 1.4047 mL 3.5117 mL
20 mM 0.1054 mL 0.5268 mL 1.0535 mL 2.6338 mL
25 mM 0.0843 mL 0.4214 mL 0.8428 mL 2.1070 mL
30 mM 0.0702 mL 0.3512 mL 0.7023 mL 1.7559 mL
40 mM 0.0527 mL 0.2634 mL 0.5268 mL 1.3169 mL
50 mM 0.0421 mL 0.2107 mL 0.4214 mL 1.0535 mL
60 mM 0.0351 mL 0.1756 mL 0.3512 mL 0.8779 mL
80 mM 0.0263 mL 0.1317 mL 0.2634 mL 0.6584 mL
100 mM 0.0211 mL 0.1054 mL 0.2107 mL 0.5268 mL
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(R)-IL-17 modulator 4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-IL-17 modulator 42446804-29-9Interleukin RelatedILIL-17 modulator 1IL-17Inhibitorinhibitorinhibit

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