IL-17 modulator 4 sulfate 

IL-17 modulator 4 sulfate is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 sulfate is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome^[1][2].

IL-17 modulator 4 sulfate (Compound 23) is a modulator for IL-17A protein-protein interaction, that stabilizes the conformation of IL-17A by binding to the central pocket of the IL-17A dimer, making it unable to effectively bind to the IL-17RA receptor, thereby inhibiting the IL-17A-mediated signaling pathway^[3].
IL-17 modulator 4 sulfate (Compound 23) inhibits glycosylated IL-17A and TNFα costimulated IL-8 secretion in HEKa cell with an EC₅₀ of 14 nM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IL-17 modulator 4 sulfate exhibits good pharmacokinetic properties in rats models with a low clearance of 7.4 mL/min/kg, a moderate volume of distribution with V_ss = 2.6 L/kg, a half-life of 3.7 h and a good oral bioavailability of 100%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

621.70

C₂₇H₃₄N₆O₂.2/3H₂O₄S

2446806-90-0

O=S(O)(O)=O.O=C(C1=CC=NN1C(C)C)N[C@H](C(NC2=CC=C(C3=C(C)NN=C3C)C=C2)=O)C(C4CC4)C5CC5.[2/3]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kevin Neil Dack, et al. Amino-acid anilides as small molecule modulators of il-17. WO2020127685A1.