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  4. (R)-L 888607

(R)-L 888607 is the isomer of L 888607 (HY-111271), and can be used as an experimental control. L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite.

For research use only. We do not sell to patients.

(R)-L 888607 Chemical Structure

(R)-L 888607 Chemical Structure

CAS No. : 2446042-90-4

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1 mg USD 140 In-stock
5 mg USD 350 In-stock
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50 mg USD 1650 In-stock
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Based on 1 publication(s) in Google Scholar

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(R)-L 888607 Related Antibodies

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Description

(R)-L 888607 is the isomer of L 888607 (HY-111271), and can be used as an experimental control. L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite[1].

Molecular Weight

375.84

Formula

C19H15ClFNO2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C[C@H]1CCN2C1=C(SC3=CC=C(Cl)C=C3)C4=C2C=C(F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (266.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6607 mL 13.3035 mL 26.6071 mL
5 mM 0.5321 mL 2.6607 mL 5.3214 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6607 mL 13.3035 mL 26.6071 mL 66.5177 mL
5 mM 0.5321 mL 2.6607 mL 5.3214 mL 13.3035 mL
10 mM 0.2661 mL 1.3304 mL 2.6607 mL 6.6518 mL
15 mM 0.1774 mL 0.8869 mL 1.7738 mL 4.4345 mL
20 mM 0.1330 mL 0.6652 mL 1.3304 mL 3.3259 mL
25 mM 0.1064 mL 0.5321 mL 1.0643 mL 2.6607 mL
30 mM 0.0887 mL 0.4435 mL 0.8869 mL 2.2173 mL
40 mM 0.0665 mL 0.3326 mL 0.6652 mL 1.6629 mL
50 mM 0.0532 mL 0.2661 mL 0.5321 mL 1.3304 mL
60 mM 0.0443 mL 0.2217 mL 0.4435 mL 1.1086 mL
80 mM 0.0333 mL 0.1663 mL 0.3326 mL 0.8315 mL
100 mM 0.0266 mL 0.1330 mL 0.2661 mL 0.6652 mL
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(R)-L 888607 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-L 8886072446042-90-4Othersthe chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2)oralCRTH2 receptorphysiologicalmetaboliteInhibitorinhibitorinhibit

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