2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor mAChR
  4. (R,R)-Reboxetine mesylate

(R,R)-Reboxetine mesylate  (Synonyms: (R,R)-FCE20124 mesylate; (R,R)-PNU155950E mesylate)

Cat. No.: HY-14560A
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(R,R)-Reboxetine mesylate is an antidepressant agent with great bioavailability. (R,R)-Reboxetine is the enantiomer of Reboxetine, which is a selective noradrenaline reuptake inhibitor. Reboxetine consists of (R,R) and (S,S) enantiomer, has low affinity for alpha-adrenergic and muscarinic receptors and low toxicity in animals.

For research use only. We do not sell to patients.

(R,R)-Reboxetine mesylate Chemical Structure

(R,R)-Reboxetine mesylate Chemical Structure

CAS No. : 105017-39-8

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Other Forms of (R,R)-Reboxetine mesylate:

(R,R)-Reboxetine mesylate Related Antibodies

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α adrenergic receptor β adrenergic receptor

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Description

(R,R)-Reboxetine mesylate is an antidepressant agent with great bioavailability. (R,R)-Reboxetine is the enantiomer of Reboxetine, which is a selective noradrenaline reuptake inhibitor. Reboxetine consists of (R,R) and (S,S) enantiomer, has low affinity for alpha-adrenergic and muscarinic receptors and low toxicity in animals[1][2].

IC50 & Target[2]

α adrenergic receptor

 

Muscarinic Receptors

 

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
0.005 μM
Compound: Reboxetine
Inhibition of the Norepinephrine transporter (NET, SLC6A2) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay in HEK-293 JumpIN-SLC6A2 cells
Inhibition of the Norepinephrine transporter (NET, SLC6A2) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay in HEK-293 JumpIN-SLC6A2 cells
[PMID: 34112854]
Molecular Weight

409.50

Formula

C20H27NO6S
CAS No.
SMILES

CCOC1=CC=CC=C1O[C@@H]([C@@]2([H])CNCCO2)C3=CC=CC=C3.CS(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R,R)-Reboxetine mesylate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-Reboxetine105017-39-8(R,R)-FCE20124(R,R)-PNU155950EAdrenergic ReceptormAChRBeta ReceptorMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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