Rabelomycin

Cat. No.: HY-114798: FAQs
Data Sheet Handling Instructions Technical Support

Rabelomycin is antibiotic, which exhibits antimicrobial activity against gram positive bacteria. Rabelomycin exhibits inhibitory activity against inducible nitric oxide synthase (iNOS) with an IC₅₀ of 63.9 μM.

For research use only. We do not sell to patients.

Rabelomycin Chemical Structure

CAS No. : 28399-50-0

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

iNOS

63.9 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	4.28 μM Compound: 8	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 23136829]
NCI-H460	IC₅₀	9.91 μM Compound: 8	Cytotoxicity against human NCI-H460 cells by SRB assay Cytotoxicity against human NCI-H460 cells by SRB assay	[PMID: 23136829]
SF-268	IC₅₀	5.54 μM Compound: 8	Cytotoxicity against human SF268 cells by SRB assay Cytotoxicity against human SF268 cells by SRB assay	[PMID: 23136829]

Molecular Weight

338.31

Formula

C₁₉H₁₄O₆

CAS No.

28399-50-0

SMILES

O=C1C2=C(C[C@@](O)(C1)C)C=C(O)C(C(C3=C(O)C=CC=C34)=O)=C2C4=O

Structure Classification

Initial Source

Microorganisms

Streptomyces sp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kharel MK, et al., Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic. Org Lett. 2010 Jun 18;12(12):2814-7. [Content Brief]

[2]. Alvi K A, et al., Identification of inhibitors of inducible nitric oxide synthase from microbial extracts[J]. The Journal of Antibiotics, 2000, 53(5): 496-501.

Rabelomycin Related Classifications

Neurological Disease Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rabelomycin28399-50-0AntibioticBacterialNO SynthaseNitric oxide synthasesNOSStreptomyces spRAW264.7focal ischemiaAlzheimer's DiseaseHuntington's diseaseInhibitorinhibitorinhibit

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