2. Anti-infection Metabolic Enzyme/Protease MAPK/ERK Pathway GPCR/G Protein
  3. Fungal Cytochrome P450 Ras
  4. Ketoconazole-d4

Ketoconazole-d4  (Synonyms: Ketoconazol-d4; R 41400-d4)

Cat. No.: HY-B0105S1 Purity: ≥98.0%
COA Handling Instructions

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Ketoconazole-d4 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

For research use only. We do not sell to patients.

Ketoconazole-d<sub>4</sub> Chemical Structure

Ketoconazole-d4 Chemical Structure

CAS No. : 1398065-75-2

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1 mg USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ketoconazole-d4:

Ketoconazole-d4 Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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K-Ras H-Ras N-Ras Ras

  • Biological Activity

  • Purity & Documentation

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Description

Ketoconazole-d4 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ketoconazole-d4 Related Antibodies
Molecular Weight

535.46

Formula

C26H24D4Cl2N4O4
CAS No.
Unlabeled CAS

65277-42-1
Appearance

Solid

Color

White to light yellow

SMILES

CC(N(CC1([2H])[2H])CC([2H])([2H])N1C(C=C2)=CC=C2OC[C@@H](CO3)O[C@]3(C4=C(C=C(C=C4)Cl)Cl)CN5C=CN=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (46.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 25 mg/mL (46.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8676 mL 9.3378 mL 18.6755 mL
5 mM 0.3735 mL 1.8676 mL 3.7351 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 1.8676 mL 9.3378 mL 18.6755 mL 46.6888 mL
5 mM 0.3735 mL 1.8676 mL 3.7351 mL 9.3378 mL
10 mM 0.1868 mL 0.9338 mL 1.8676 mL 4.6689 mL
15 mM 0.1245 mL 0.6225 mL 1.2450 mL 3.1126 mL
20 mM 0.0934 mL 0.4669 mL 0.9338 mL 2.3344 mL
25 mM 0.0747 mL 0.3735 mL 0.7470 mL 1.8676 mL
30 mM 0.0623 mL 0.3113 mL 0.6225 mL 1.5563 mL
40 mM 0.0467 mL 0.2334 mL 0.4669 mL 1.1672 mL
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Ketoconazole-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ketoconazole-d41398065-75-2Ketoconazol-d4R 41400-d4FungalCytochrome P450RasCYPsInhibitorinhibitorinhibit

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