2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. (±)-Abscisic acid

(±)-Abscisic acid  (Synonyms: (±)-ABA)

Cat. No.: HY-N2549 Purity: 99.91%
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(±)-Abscisic acid ((±)-ABA) is an orally active phytohormone. (±)-Abscisic acid induces Ca2+ channel opening to facilitate the influx of calcium ions and modulates stomatal movement. (±)-Abscisic acid shows anti-inflammatory activity and has the potential for the research of inflammatory bowel disease (IBD).

For research use only. We do not sell to patients.

(±)-Abscisic acid Chemical Structure

(±)-Abscisic acid Chemical Structure

CAS No. : 14375-45-2

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5 mg USD 32 In-stock
10 mg USD 50 In-stock
25 mg USD 110 In-stock
50 mg USD 190 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (±)-Abscisic acid:

(±)-Abscisic acid Related Antibodies

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Description

(±)-Abscisic acid ((±)-ABA) is an orally active phytohormone. (±)-Abscisic acid induces Ca2+ channel opening to facilitate the influx of calcium ions and modulates stomatal movement. (±)-Abscisic acid shows anti-inflammatory activity and has the potential for the research of inflammatory bowel disease (IBD)[1][2].

In Vitro

(±)-Abscisic acid (10 µM; 20 h) increase CTLA-4 expression in cultured lymphocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(±)-Abscisic acid Related Antibodies

Immunofluorescence[2]

Cell Line: lymphocytes
Concentration: 10 µM
Incubation Time: 20 h
Result: Significantly increased the percentage of CTLA-4 expressing cells and enhanced CTLA-4 median fluorescence intensity (MFI) on CD4+ T cells expressing PPAR γ.
In Vivo

(±)-Abscisic acid (100 mg/kg; fed) significantly ameliorates disease activity, colitis and reduces colonic leukocyte infiltration and inflammation in colitis mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, C57BL/6J mice (2.5% dextran sodium sulfate (DSS) induces colitis)[2]
Dosage: 100 mg/kg
Administration: Fed for 35 days
Result: Reduced disease activity and colonic inflammation, improved colon histopatholgy and reduces leukocyte infiltration, suppressed colonic expression of adhesion molecules.
Molecular Weight

264.32

Formula

C15H20O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C=C(C)\C=C\C1(O)C(C)=CC(CC1(C)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (945.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7833 mL 18.9165 mL 37.8329 mL
5 mM 0.7567 mL 3.7833 mL 7.5666 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (7.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (7.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.91%

SDS (393 KB)

COA (247 KB) HNMR (263 KB) LCMS (273 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7833 mL 18.9165 mL 37.8329 mL 94.5823 mL
5 mM 0.7567 mL 3.7833 mL 7.5666 mL 18.9165 mL
10 mM 0.3783 mL 1.8916 mL 3.7833 mL 9.4582 mL
15 mM 0.2522 mL 1.2611 mL 2.5222 mL 6.3055 mL
20 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7291 mL
25 mM 0.1513 mL 0.7567 mL 1.5133 mL 3.7833 mL
30 mM 0.1261 mL 0.6305 mL 1.2611 mL 3.1527 mL
40 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3646 mL
50 mM 0.0757 mL 0.3783 mL 0.7567 mL 1.8916 mL
60 mM 0.0631 mL 0.3153 mL 0.6305 mL 1.5764 mL
80 mM 0.0473 mL 0.2365 mL 0.4729 mL 1.1823 mL
100 mM 0.0378 mL 0.1892 mL 0.3783 mL 0.9458 mL
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(±)-Abscisic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-Abscisic acid14375-45-2(±)-ABACalcium ChannelCa2+ channelsCa channelsanti-inflammatoryCa2+stomatal movementinflammatory bowel diseaseCTLA-4orally activeInhibitorinhibitorinhibit

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