2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Raloxifene 4-Monomethyl Ether

Raloxifene 4-Monomethyl Ether (Compound 37) is a Raloxifene derivative that inhibits estrogen receptor α. Raloxifene 4-Monomethyl Ether inhibits MCF-7 cells with an IC50 of 1 μM and a pIC50 of 6.

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Raloxifene 4-Monomethyl Ether Chemical Structure

Raloxifene 4-Monomethyl Ether Chemical Structure

CAS No. : 185415-07-0

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Description

Raloxifene 4-Monomethyl Ether (Compound 37) is a Raloxifene derivative that inhibits estrogen receptor α. Raloxifene 4-Monomethyl Ether inhibits MCF-7 cells with an IC50 of 1 μM and a pIC50 of 6[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
1000 nM
Compound: 5b
Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro)
Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro)
[PMID: 9003514]
Molecular Weight

487.61

Formula

C29H29NO4S
CAS No.
SMILES

O=C(C1=C(C2=CC=C(OC)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Raloxifene 4-Monomethyl Ether Related Classifications

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Keywords:

Raloxifene 4-Monomethyl Ether185415-07-0Estrogen Receptor/ERRERαRaloxifenederivativeInhibitorinhibitorinhibit

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