Ramentaceone (Synonyms: 7-Methyljuglon)

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Ramentaceone (7-Methyljuglon), a naphthoquinone that can be isolated from Drosera sp., inhibits PI3K activity. Ramentaceone (7-Methyljuglon) reduces the expression of the PI3K protein and inhibits the phosphorylation of the Akt protein in breast cancer cells. Ramentaceone (7-Methyljuglon) induces apoptosis.

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Ramentaceone Chemical Structure

CAS No. : 14787-38-3

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•Related Small Molecules:

•Related Proteins:

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View All Isoforms

PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	11.9 μM Compound: 1	Cytotoxicity against human DU145 cells assessed as cell survival after 24 hrs by XTT assay Cytotoxicity against human DU145 cells assessed as cell survival after 24 hrs by XTT assay	[PMID: 25059501]
HeLa	IC₅₀	66.6 μM Compound: 1	Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by XTT assay Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by XTT assay	[PMID: 25059501]
HL-60	IC₅₀	8.75 μM Compound: 1, 7-methyljuglone	Cytotoxicity against human HL60 cells after 24 hrs by MTT assay Cytotoxicity against human HL60 cells after 24 hrs by MTT assay	[PMID: 22250825]
MCF7	IC₅₀	27.2 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as cell survival after 24 hrs by XTT assay Cytotoxicity against human MCF7 cells assessed as cell survival after 24 hrs by XTT assay	[PMID: 25059501]
NFF	IC₅₀	7.6 μM Compound: 2	Cytotoxicity against human NFF cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay Cytotoxicity against human NFF cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay	[PMID: 33314932]
PBMC	IC₅₀	18.4 μM Compound: 1	Cytotoxicity against human PBMC assessed as cell survival after 24 hrs by XTT assay Cytotoxicity against human PBMC assessed as cell survival after 24 hrs by XTT assay	[PMID: 25059501]
Vero	IC₅₀	15.1 μg/mL Compound: 6	Cytotoxicity against Vero cells after 48 hrs by XTT method Cytotoxicity against Vero cells after 48 hrs by XTT method	[PMID: 17888665]

Molecular Weight

188.18

Formula

C₁₁H₈O₃

CAS No.

14787-38-3

SMILES

O=C1C=CC(C2=C1C=C(C)C=C2O)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Anna Kawiak, et al. Ramentaceone, a Naphthoquinone Derived from Drosera sp., Induces Apoptosis by Suppressing PI3K/Akt Signaling in Breast Cancer Cells. PLoS One. 2016 Feb 3;11(2):e0147718. [Content Brief]

Ramentaceone Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ramentaceone14787-38-37-MethyljuglonPI3KApoptosisPhosphoinositide 3-kinaseAktapoptosisInhibitorinhibitorinhibit

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