2. Anti-infection
  3. HCV
  4. Ravidasvir hydrochloride

Ravidasvir hydrochloride  (Synonyms: PPI-668 hydrochloride)

Cat. No.: HY-124191 Purity: 99.94%
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Ravidasvir hydrochloride (PPI-668 hydrochloride) is a pan-genotypic inhibitor for hepatitis C virus (HCV) NS5A protein. Ravidasvir hydrochloride inhibits the replication of HCV, with EC50 of 0.12, 0.01 and 1.14 nM, for HCV gt-1a, gt-1b, and gt-3a replicons, respectively. Ravidasvir hydrochloride exhibits good pharmacokinetic characters in rats.

For research use only. We do not sell to patients.

Ravidasvir hydrochloride Chemical Structure

Ravidasvir hydrochloride Chemical Structure

CAS No. : 1303533-81-4

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Based on 1 publication(s) in Google Scholar

Ravidasvir hydrochloride Related Antibodies

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Description

Ravidasvir hydrochloride (PPI-668 hydrochloride) is a pan-genotypic inhibitor for hepatitis C virus (HCV) NS5A protein. Ravidasvir hydrochloride inhibits the replication of HCV, with EC50 of 0.12, 0.01 and 1.14 nM, for HCV gt-1a, gt-1b, and gt-3a replicons, respectively. Ravidasvir hydrochloride exhibits good pharmacokinetic characters in rats[1].

Molecular Weight

835.82

Formula

C42H52Cl2N8O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C2=NC3=CC=C(C4=CC5=C(C=C(C6=CN=C([C@H]7N(CCC7)C([C@H](C(C)C)NC(OC)=O)=O)N6)C=C5)C=C4)C=C3N2)=O)=O.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (149.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1964 mL 5.9821 mL 11.9643 mL
5 mM 0.2393 mL 1.1964 mL 2.3929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1964 mL 5.9821 mL 11.9643 mL 29.9107 mL
5 mM 0.2393 mL 1.1964 mL 2.3929 mL 5.9821 mL
10 mM 0.1196 mL 0.5982 mL 1.1964 mL 2.9911 mL
15 mM 0.0798 mL 0.3988 mL 0.7976 mL 1.9940 mL
20 mM 0.0598 mL 0.2991 mL 0.5982 mL 1.4955 mL
25 mM 0.0479 mL 0.2393 mL 0.4786 mL 1.1964 mL
30 mM 0.0399 mL 0.1994 mL 0.3988 mL 0.9970 mL
40 mM 0.0299 mL 0.1496 mL 0.2991 mL 0.7478 mL
50 mM 0.0239 mL 0.1196 mL 0.2393 mL 0.5982 mL
60 mM 0.0199 mL 0.0997 mL 0.1994 mL 0.4985 mL
80 mM 0.0150 mL 0.0748 mL 0.1496 mL 0.3739 mL
100 mM 0.0120 mL 0.0598 mL 0.1196 mL 0.2991 mL
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Ravidasvir hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ravidasvir1303533-81-4PPI-668PPI668PPI 668HCVHepatitis C virusNS5Apan-genotypicInhibitorinhibitorinhibit

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